Bone Marrow Cell-Seeded Biodegradable Polymeric Scaffold Enhances Angiogenesis and Improves Function of the Infarcted Heart
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概要
- 論文の詳細を見る
Background The present study examined whether a bioengineered polyglycolic acid cloth (PGAC) impregnated with bone marrow cells (BMC) improved the function and angiogenesis of the infarcted heart. Methods and Results The coronary artery was ligated in Lewis rats and the infarcted area was covered with a PGAC in group 1 (n=8), with a PGAC containing basic-fibroblast growth factor (b-FGF) in group 2 (n=11) and a PGAC containing b-FGF and freshly isolated BMC in group 3 (n=10). In addition, BMC derived from transgenic mice expressing green fluorescent protein (GFP)-BMC were seeded into a PGAC, which was sutured over the infarcted area of C57BL/6 mice (n=5). In the rat study, developed and systolic pressures, dp/dt max and dp/dt min) were the highest in group 3, as were the capillary density in the PGAC and infarcted area. In the mouse study, there were few GFP-BMC in the PGAC, but none in the infarcted area. Conclusions A PGAC with BMC improved cardiac function by inducing angiogenesis without migration of BMC. Freshly isolated BMC work as angiogenic inducers and a PGAC is useful as a "drug delivery system".
- 社団法人日本循環器学会の論文
- 2005-06-20
著者
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Yutani Chikao
Department Of Pathology National Cardiovascular Center
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Yutani Chikao
Department Of Life Science Okayama University Of Science
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Kitamura Soichiro
Cardiovascular Surgery, National Cardiovascular Center
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Nakatani Takeshi
Organ Transplant, National Cardiovascular Center
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由谷 親夫
Department Of Pathology National Cardiovascular Center
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TOMITA Shinji
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center
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Fukuhara Shinya
Departments of Regenerative Medicine and Tissue Engineering
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Fujisato Toshiya
Departments of Regenerative Medicine and Tissue Engineering
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Ohtsu Yoshinori
Departments of Regenerative Medicine and Tissue Engineering
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Ishida Michiko
Departments of Regenerative Medicine and Tissue Engineering
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Fukuhara Shinya
National Cardiovascular Center
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Ohtsu Yoshinori
National Cardiovascular Center
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Ishida Michiko
National Cardiovascular Center
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Fujisato Toshiya
Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center
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Funahashi Tohru
Department Of Internal Medicine And Molecular Science Osaka University Graduate School Of Medicine
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Tomita Shinji
Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center
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Tomita Shinji
Department Of Cardiovascular Surgery And Cardiology Nagara Medical Center
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Fukuhara Shinya
Department Of Pathology National Cardiovascular Center
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Kitamura Soichiro
Cardiovascular Division Of In-ternal Medicine National Cardiovascular Center
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Nakatani Takeshi
Organ Transplantation National Cardiovascular Center
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Ishida Michiko
Department Of Cardiovascular Surgery Fujita Health University
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Fujisato Toshiya
Department Of Biomedical Engineering Osaka Institute Of Technology
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Nishimura Takashi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Shishido Toshiaki
Department Of Cardiovascular Dynamics National Cerebral And Cardiovascular Center
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Nakatani Takeshi
Division Of Cardiovascular Surgery National Cardiovascular Center
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Yutani Chikao
Department Of Life Science Faculty Of Science Okayama University Of Science
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Yutani Chikao
Department Of Clinical Laboratory National Cardiovascular Center
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Tomita Shinji
Department Of Cardiovascular Dynamics National Cerebral And Cardiovascular Center
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Yutani Chikao
The Department Of Pathology National Cardiovascular Center
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Ohtsu Yoshinori
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center
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KITAMURA Soichiro
Cardiovascular and Transplant Surgery, National Cerebral and Cardiovascular Center
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