The Interaction between Proton Pump Inhibitors and Warfarin in Patients with Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
<B>Background:</B> Although warfarin is potentiated by omeprazole through interference of the cytochrome P450 system, little is known in other proton pump inhibitors (PPIs). We evaluated the interactions between warfarin and lansoprazole/sodium rabeprazole. <B>Methods:</B> This retrospective study consisted of 161 atrial fibrillation (AF) patients who underwent catheter ablation of AF. Optimal anticoagulation treatment by warfarin was performed in all patients without taking PPIs prior to procedure. Following ablation, 15 mg of lansoprazole or 10 mg of sodium rabeprazole was administered in patients presenting Gastrointestinal discomfort. We investigated the dose of warfarin required to maintain optimal prothrombin time international normalized ratio (PT-INR) before the procedure and at 3 months after administration of PPIs. <B>Results:</B> Lansoprazole and sodium rabeprazole were administered in 62 and 63 patients with gastroesophagitis symptom, respectively. There were no significant differences in dose of warfarin between before and after taking lansoprazole (4.0±1.2 mg/day vs. 4.1±1.2 mg/day, p=NS)/rabeprazole (3.8±1.0 mg/day vs. 3.8±1.1 mg/day, p=NS). Additionally, no differences were observed in the value of PT-INR between before and after taking PPIs in patients with lansoprazole (1.9±0.3 vs. 2.0±0.5, P=NS) and rabeprazole (2.1±0.4 vs. 2.1±0.5, P=NS). <B>Conclusion:</B> Lansoprazole and rabeprazole could be safely used in patients with anticoagulant treatment by warfarin.
著者
-
Inada Keiichi
the Departure of Cardiology, Jikei University School of medicine
-
Date Taro
the Departure of Cardiology, Jikei University School of medicine
-
Yoshimura Michihiro
The Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
-
Yamane Teiichi
The Department of Cardiology, The Jikei University School of Medicine
-
Yamashita Seigo
The Department of Cardiology, The Jikei University School of Medicine
-
Matsuo Seiichiro
The Department of Cardiology, The Jikei University School of Medicine
-
Hioki Mika
The Department of Cardiology, The Jikei University School of Medicine
-
Narui Ryohsuke
The Department of Cardiology, The Jikei University School of Medicine
-
Ito Keiichi
The Department of Cardiology, The Jikei University School of Medicine
-
Tanigawa Shin-ichi
The Department of Cardiology, The Jikei University School of Medicine
-
Sugimoto Ken-ichi
The Department of Cardiology, The Jikei University School of Medicine
-
Tokutake Ken-ichi
The Department of Cardiology, The Jikei University School of Medicine
-
Yoshimura Michihiro
The Department of Cardiology, The Jikei University School of Medicine
-
Inada Keiichi
The Department of Cardiology, The Jikei University School of Medicine
-
Date Taro
The Department of Cardiology, The Jikei University School of Medicine
関連論文
- 2 The Effects of Statin for Coronary Artery Spasm(Recent Progress in the Management of Vasospastic Angina,Meet the Expert 6 (ME-6) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-343 Effects of the Infusion of A-type Natriuretic Hormone (ANP) on the Activity of Hypothalamic-Pitultary-Adrenal Axis in Patients With Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japan
- PE-239 The Effects of Statins on Coronary Artery Spasm (S-CAST Study)(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-259 Reconnection after Electrical Isolation is More Frequent in the Superior Vena Cava than Pulmonary Vein(Arrhythmia, therapy(08)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-377 The-786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene is Associated with Calcium Channel Blocker Resistant Coronary Spasm(Angina pectoris, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Heart Failure with Silent Coronary Artery Spasm Exhibiting Microscopic Focal Myocardial Necrosis and Amyloid-Deposition
- PE-013 The -786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene is a Predictive Factor for Rehospitalizaion for Pure Coronary Spasm(Angina pectoris, basic/clinical-3 (IHD) PE3,Poster Session (English),The 70th Anniversary Annual Scientific M
- Vascular Responsiveness to Angiotensin II and Phenylephrine, the Tubular Function and the Prostaglandin, Renin-Angiotensin System in a Patient with Bartters Syndrome
- The Association between Dissociated Pulmonary Vein Activity and Types of Recurrence in Paroxysmal Atrial Fibrillation Patients
- Induction of Atrial Fibrillation by Isoproterenol and Adenosine: The Importance of Concurrent Administration to Access the AF Inducibility
- The Impact of Early Reverse Remodeling after Ablation Procedure on a Long-Term Outcome in Patients with Paroxysmal Atrial Fibrillation
- Procedure-Related Thromboembolism in Patients Underwent Atrial Fibrillation Ablation by Using an Open Irrigated Ablation Catheter
- Registration of 3D Rotational Angiogram of the Heart and Esophagus on the Fluoroscopic View
- The Interaction between Proton Pump Inhibitors and Warfarin in Patients with Atrial Fibrillation