EFFECTS OF YS-980, AN ORALLY ACTIVE CONVERTING ENZYME INHIBITOR, ON BLOOD PRESSURE IN NORMOTENSIVE AND HYPERTENSIVE RATS
スポンサーリンク
概要
- 論文の詳細を見る
The hypotensive effect of YS-980, (4R)-3-[(2S)-3-mercapto-2-methyl propanoyl]-4-thiazolidinecarboxylic acid, was investigated in normotensive and different models of hypertensive rats. Experiments were carried out in both anesthetized rats (1 mg/kg i.v.), and conscious unrestrained rats (10 mg/kg p.o.). YS-980 markedly lowered blood pressure in acute renal hypertensive and two-kidney, one-clip hypertensive rats and moderately lowered the pressure in SHR. Contrary to these hypotensive effects, this agent did not reduce the blood pressure in DOCA hypertensive rats. In normotensive rats, YS-980 had a slight hypotensive action in anesthetized rats but not in the conscious animals. The hypotensive effect of YS-980 is attributed mainly to suppression of the reninangiotensin system.
- 社団法人 日本薬理学会の論文
著者
-
Yamamoto Kenjiro
Department Of Pharmacology Osaka City University Medical School
-
Komori Tadamitsu
Department Of Pharmacology Osaka City University Medical School
関連論文
- EFFECTS OF PROSTAGLANDIN I_2 AND E_2 ON RENAL HEMODYNAMICS AND FUNCTION AND RENIN RELEASE
- Effects of Calcium Ionophore, A23187, on Prostaglandin E_2 and Renin Release in Dogs : IX Conference on the Pathogenesis of Hypertension
- EFFECTS OF OUABAIN ON RENIN SECRETION : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- -EFFECT OF CALCIUM AND CALCIUM ANTAGONISTS ON RENAL FUNCTIONS AND RENIN RELEASE IN DOGS : IInd Auditorium
- Control of Renin Secretion : SYMPOSIUM ON PATHOGENESIS OF ESSENTIAL HYPERTENSION
- Effect of Ca on Renin Release in Vitro and in Vivo (3 Conference of Pathogenesis of Hypertension)
- Renin-Angiotensin System in Genetically Hypertensive Mice : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Subcellular Localization of Exogenously Administered Renin in Mouse Kidney : The 12th Conference on the Pathogenesis of Hypertension
- Sandwich Radioimmunoassay of Human Plasma Renin Using Two Monoclonal Antibodies : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Storage Form of Renin in the Dog Kidney : VII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Inhibition of Dog Renin Activity by Pepstatin A : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Relationship between Molecular Weight Conversion and Renin Activity in Dog Renal Renin : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- RENIN RELEASE FROM ISOLATED RENIN GRANULES : IIIrd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EFFECTS OF N-MERCAPTOACYLAMINO ACIDS ON INHIBITION OF ANGIOTENSIN I CONVERTING ENZYME
- -239-THE SECRETION OF ACTIVE AND INACTIVE FORMS OF RENIN IN THE DOG : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- RENIN INHIBITORY EFFECT OF N-ACETYL-PEPSTATIN
- EFFECTS OF RENAL VENOUS PRESSURE ELEVATION ON RENAL HEMODYNAMICS, URINE FORMATION AND RENIN RELEASE
- CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG (3) EFFECTS OF HYPERTONIC MANNITOL INFUSION
- Control of Renin Secretion in the Anesthetized Dog 2) Relationship between Renin Secretion, Plasma Sodium Concentration and GFR in the Perfused Kidney
- Effects of Cyclic AMP and Dibutyryl Cyclic AMP on Renin Release in Vivo and in Vitro
- DIURETIC ACTION OF METOLAZONE IN DOGS
- EFFECT OF INTRARENAL ARTERIAL INFUSION OF CALCIUM ON RENIN RELEASE IN DOGS
- Renin Inhibition by Synthetic Phosphatidyl and Phosphorylethanolamines
- EFFECTS OF EDTA AND VERAPAMIL ON RENIN RELEASE IN DOGS
- INTRARENAL ROLE OF RENIN-ANGIOTENSIN SYSTEM IN THE REGULATION OF RENAL HEMODYNAMICS
- Relationship between Renin Secretion and Renal Autoregulation in the dogs
- STUDY OF HYPERTENSION : INTRAVENOUS AND INTRAVENTRICULAR ADMINISTRATION EFFECT OF ANGIOTENSIN II ON CARDIO-VASCULAR SYSTEM
- Diuretic Action of Isoproterenol in the Dog
- EFFECT OF DIURETICS ON ION TRANSPORT OF KIDNEY CORTEX MITOCHONDRIA III. SPECIES DIFFERENCE IN CALCIUM ACCUMULATION AND IN ETHACRYNIC ACID EFFECT
- EFFECTS OF YS-980, AN ORALLY ACTIVE CONVERTING ENZYME INHIBITOR, ON BLOOD PRESSURE IN NORMOTENSIVE AND HYPERTENSIVE RATS
- Renal Effects of Specific Antagonists of Arginine Vasopressin in Dogs
- Effects of an angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.
- Differences between SHR and WKY in Content of Cytochrome P-450 Isozymes Which Contribute Arachidonic Acid Metabolism
- Angiotensin converting enzyme inhibitory substance exists in the rat heart
- High molecular weight renin in the plasma and kidney of SHRSP