Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice
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概要
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We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK1R.
- 社団法人 日本薬理学会の論文
著者
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Yamamoto Kouichi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Yamatodani Atsushi
Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni
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Ikeda Toshiji
Department Of Accelerator Science The Institute Of Scientific And Industrial Research Osaka Universi
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Kureyama Naoko
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Asano Keiko
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamamoto Kouichi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamamoto Kouichi
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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Ikeda Toshiji
Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Japan
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Asano Keiko
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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Yamatodani Atsushi
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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