Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H_1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate-Sensitized Rats
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概要
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Antihistamines are effective for treatment of seasonal nasal allergy. Recently, prophylactic treatment with antihistamines in patients with pollinosis was reported to be more effective when started before the pollen season. The administration with antihistamines from 2 to 6 weeks before onset of the pollen season is recommended for management of allergic rhinitis in Japan. To determine the reason for the effectiveness of prophylactic treatment with antihistamines, the effects of repeated pre-treatment with antihistamines before provocation with toluene 2,4-diisocyanate (TDI) on their nasal allergy–like behavior and up-regulations of histamine H1 receptors (H1R) and interleukin (IL)-4 mRNAs in their nasal mucosa were examined. Provocation with TDI induced sneezing and up-regulations of H1R and IL-4 mRNAs in the nasal mucosa of TDI-sensitized rats. Repeated pre-treatments with antihistamines including epinastine, olopatadine, or d-chlorpheniramine for 1 to 5 weeks before provocation with TDI suppressed TDI-induced sneezing and the up-regulations of H1R and IL-4 mRNAs in the nasal mucosa more than their administrations once or for 3 days before TDI provocation. Our data indicate that repeated pre-treatment with antihistamines before provocation with TDI is more effective than their single treatment in reducing nasal allergy–like behavior by causing additional suppression of up-regulations of H1R and IL-4 mRNAs in the nasal mucosa.
- 社団法人 日本薬理学会の論文
- 2008-12-20
著者
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Mizuguchi Hiroyuki
Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka
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TAKEDA Noriaki
Department of Medical Systems Management, Faculty of Medicine, Kagawa Medical University
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FUKUI Hiroyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokushima
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MATSUSHITA Chiyo
Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima G
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FUKUI Hiroyuki
Yao Municipal Hospital
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Matsushita Chiyo
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Matsushita Chiyo
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Gra
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Fukui Hiroyuki
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Fukui Hiroyuki
徳島大学 ヘルスバイオサイエンス研究部耳鼻咽喉科学
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Hatano Masaya
Department Of Molecular Pharmacology Institute Of Health-biosciences The University Of Tokushima Gra
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Takeda Noriaki
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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UMEHARA Hayato
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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KURODA Wakana
Department of Otolaryngology, Institute of Health-Biosciences, The University of Tokushima Graduate
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KITAMURA Yoshiyuki
Department of Otolaryngology, Institute of Health-Biosciences, The University of Tokushima Graduate
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Kuroda Wakana
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Umehara Hayato
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Mizuguchi Hiroyuki
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Kitamura Yoshiaki
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Takeda Noriaki
Department Of Medical Social Work Faculty Of Medical Welfare Kawasaki University Of Medical Welfare
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Fukui Hiroyuki
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Gra
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Fukui Hiroyuki
Department Of Medicine Yao City Hospital
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Kitamura Yoshiaki
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Takeda Noriaki
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Hatano Masaya
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate School
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Hattori Masashi
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate School
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