Analysis of Beta3 Adrenergic Receptor Gene Polymorphism Using Noninvasive Samples Obtained at Scheduled Infant Health Checkups

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概要

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• Obesity is a risk factor for life-style-related diseases, and is based on three factors : genetic, environmental, and life-style. In adults, it is difficult to achieve and maintain normal body weight, so it is more effective to intervene from infancy to establish weight control. Legally required health checkups in infants of 18 and 36 months present important opportunities for obesity prevention. We consider genetic analysis to be a very important factor for obesity prevention in infancy. However, since health checkups don't involve the collection of blood, genetic analysis is considered difficult. In this study, we attempted the typing of beta3 adrenergic receptor gene polymorphism as a genetic factor from non-invasively obtained samples, buccal mucosa, hair and cerumen in 96 infants at their 18- and 36-month health checkups. Sampling buccal mucosa, hair and cerumen instead of blood caused almost no anxiety to the child or parent, so 94.1% cooperation with sampling was obtained. From buccal mucosa, about 76% of the samples could be used for the typing of polymorphism (81% by enzyme method, 59% by kit method). From hair, about 44% of the samples permitted typing of polymorphism, but from cerumen only about 4% of the samples could be used. Results from buccal mucosa and hair typed about 90% of infant polymorphism. These results suggest that this method would be practical at periodic health checkups, and would probably be applicable to mass screenings for genetic factor analysis for other diseases.

• 日本衛生学会の論文

著者

• JITSUNARI Fumihiko

  Department of Hygiene & Public Health, Faculty of Medicine, Kagawa Medical University

• SUNA Shigeru

  Department of Hygiene & Public Health, Faculty of Medicine, Kagawa Medical University

• TAKEDA Noriaki

  Department of Medical Systems Management, Faculty of Medicine, Kagawa Medical University

• Takeda Noriaki

  Department Of Medical Systems Management School Of Medicine Kagawa Medical University

• SATO Chubun

  Departments of Molecular Biology, Kagawa Medical University

• Sato Chubun

  Department Of Molecular Biology School Of Medicine Kagawa Medical University

• Jitsunari Fumihiko

  Kagawa Univ. Kagawa Jpn

• Takeda Noriaki

  Department Of Medical Social Work Faculty Of Medical Welfare Kawasaki University Of Medical Welfare

• ASAKAWA Fumiyuki

  Human-Environmental Science Research Laboratory, College of Life Science, Kurashiki University of Sc

• TADOKORO Masaya

  Department of Hygiene and Public Health, School of Medicine, Kagawa Medical University

• Tadokoro Masaya

  Department Of Hygiene And Public Health School Of Medicine Kagawa Medical University

• SATO CHUBUN

  Department of Biology, Faculty of Science, Okayama University

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