Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat
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概要
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An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H1–receptor (H1R) mRNA in toluene 2,4-diisocyanate (TDI)-sensitized rats. Although pre-treatment with pranlukast partially, but significantly, suppressed TDI-induced up-regulation of H1R mRNA and nasal symptoms, pre-treatment with the combination of pranlukast and chlorpheniramine significantly suppressed them in a manner greater than either drug alone. These findings suggest that the additive therapeutic effect of the combination of LTR antagonist and antihistamine is due to their additive suppression of H1R up-regulation.
著者
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Mizuguchi Hiroyuki
Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka
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Kuroda Wakana
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Kitamura Yoshiaki
Department Of Otolaryngology Institute Of Health-biosciences The University Of Tokushima Graduate Sc
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Takeda Noriaki
Department Of Medical Social Work Faculty Of Medical Welfare Kawasaki University Of Medical Welfare
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Kalubi Bukasa
Department Of Otolaryngology Graduate School Of Health-biosciences The University Of Tokushima
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Fukui Hiroyuki
Department Of Medicine Yao City Hospital
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Miyamoto Yuko
Department of Obstetrics and Gynecology, Oita University, Faculty of Medicine
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Mizuguchi Hiroyuki
Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
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Fukui Hiroyuki
Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
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