Kujin Suppresses Histamine Signaling at the Transcriptional Level in Toluene 2,4-Diisocyanate-Sensitized Rats
スポンサーリンク
概要
- 論文の詳細を見る
Kujin, the dried root of Sophorae flavescensis, has been used in Chinese folklore medicine against allergy. Evaluation of its anti-allergic potential as well as its mechanism of action has rarely been established. We investigated the effect of Kujin on toluene-2,4-diisocyanate (TDI)-induced allergic behavior and related histamine signaling including mRNA levels of histamine H1 receptor (H1R) and histidine decarboxylase (HDC), H1R and HDC activities, and histamine content in rat nasal mucosa. We also investigated the effect of Kujin on the mRNA levels of helper T cell type 2 (Th2)-cytokine genes closely related to histamine signaling. TDI provocation caused acute allergic symptoms accompanied with up-regulations of H1R and HDC mRNAs and increases in HDC activity, histamine content, and [3H]mepyramine binding activity in the nasal mucosa, all of which were significantly suppressed by pretreatment with Kujin for 3 weeks. Kujin also suppressed the TDI-induced IL-4 and IL-5 mRNA elevations. These data suggest that oral administration of Kujin showed anti-allergic activity through suppression of histamine signaling by the inhibition of TDI-induced H1R and HDC mRNA elevations followed by decrease in H1R, HDC protein level, and histamine content in the nasal mucosa of TDI-sensitized rats. Suppression of Th2-cytokine signaling by Kujin also suggests that it could affect the histamine-cytokine network.
- 社団法人 日本薬理学会の論文
- 2009-04-20
著者
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Mizuguchi Hiroyuki
Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka
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HATTORI Masashi
Department of Chemistry, Graduate School of Science, Osaka University
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FUKUI Hiroyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokushima
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FUKUI Hiroyuki
Yao Municipal Hospital
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Fukui Hiroyuki
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Fukui Hiroyuki
徳島大学 ヘルスバイオサイエンス研究部耳鼻咽喉科学
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Das Asish
Dep. Of Molecular Pharmacology Inst. Of Health-biosciences The Univ. Of Tokushima Graduate School Jp
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Hatano Masaya
Department Of Molecular Pharmacology Institute Of Health-biosciences The University Of Tokushima Gra
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Hattori Masashi
Department Of Applied Physics Graduate School Of Engineering Tohoku University
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DEV Shrabanti
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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DAS Asish
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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MAEYAMA Kazutaka
Division of Pharmacology, Department of Integrated Basic Medical Science, Ehime University School of
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HORINAGA Shiho
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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KATO Shuhei
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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TAMADA Misaki
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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UMEHARA Hayato
Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima G
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Das Asish
Department Of Molecular Pharmacology Graduate School Of Health Biosciences The University Of Tokushi
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Dev Shrabanti
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Das Asish
Departments Of Molecular Pharmacology Graduate School Of Health-biosciences The University Of Tokush
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Kato Shuhei
Department Of Molecular Pharmacology Institute Of Health-biosciences The University Of Tokushima Gra
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Horio Shuhei
Department Of Molecular Pharmacology Institute Of Health-biosciences The University Of Tokushima Gra
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Tamada Misaki
Department Of Molecular Pharmacology Institute Of Health-biosciences The University Of Tokushima Gra
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Umehara Hayato
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Mizuguchi Hiroyuki
Department Of Molecular Pharmacology The University Of Tokushima Graduate School
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Fukui Hiroyuki
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Gra
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Maeyama Kazutaka
Division Of Pharmacology Department Of Integrated Basic Medical Science Ehime University School Of M
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Maeyama Kazutaka
Division Of Pharmacology Department Of Integrated Basic Medical Science Ehime University School Of M
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Fukui Hiroyuki
Department Of Medicine Yao City Hospital
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Hattori Masashi
Department Of Molecular Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate School
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