Functional expression of H1-histaminergic receptors in Xenopus laevis oocytes injected with bovine adrenal medullary mRNA.
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概要
- 論文の詳細を見る
We prepared poly (A)<SUP>+</SUP> mRNA from bovine adrenal medulla and electro physiologically examined the expression of H<SUB>1</SUB>-histaminergic receptors in <I>Xenopus laevis</I> oocytes. Histamine dose-dependently induced inward currents in oocytes injected with the mRNA, but not in those injected with water or the non-injected oocytes. This response was also induced by H<SUB>1</SUB>-agonists and antagonized by H<SUB>1</SUB>-antagonists, while both an H<SUB>2</SUB>-agonist and an antagonist had no effect. These results clearly demonstrate that H<SUB>1</SUB>-histaminergic receptors are functionally expressed in oocytes injected with exogenous mRNA.
- 公益社団法人 日本薬理学会の論文
著者
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Yamashita Masakatsu
Department Of Immunology Graduate School Of Medicine Chiba University
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Fukui Hiroyuki
Department Of Medicine Yao City Hospital
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Wada Hiroshi
Department Of Bioengineering And Robotics Tohoku University
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Ito Seiji
Department Of Applied Chemistry And Biotechnology Interdisciplinary Graduate School Of Medicine And Engineering University Of Yamanashi
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Sugama Kazushige
Department of Cell Biology, Osaka Bioscience Institute
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Yamashita Masakatsu
Department of Pharmacology II, Osaka University School of Medicine
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