Characterization of Dextran Sulfate-Induced Guinea Pig Tracheal Plasma Extravasation
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概要
- 論文の詳細を見る
We examined the effect of dextran sulfate on guinea pig tracheal vascular permeability. I. v. injection of dextran sulfate (10-100 mg/kg) with captopril (1 mg/kg) induced guinea pig tracheal plasma extravasation. The i. v. administration of bradykinin (0.8-8 μg/kg) with captopril (1 mg/kg) also induced plasma extravasation. Bradykinin B<SUB>2</SUB> antagonists, D-Arg[Hyp<SUP>3</SUP>-Thi<SUP>5</SUP>-D-Tic<SUP>7</SUP>-Tic<SUP>8</SUP>]-bradykinin (NPC 16731) and D-Arg[Hyp<SUP>3</SUP>-Thi<SUP>5</SUP>-D-Tic<SUP>7</SUP>-0ic<SUP>8</SUP>]-bradykinin (Hoe 140), reduced both dextran sulfate (32 mg/kg)- and bradykinin (2.5 μg/kg)-induced tracheal plasma extravasation in a dose-dependent manner. However, a cyclooxygenase inhibitor, indomethacin (1 mg/kg), and a neurokinin antagonist, {<I>N</I>-[<I>N</I><SUP>2</SUP>-[<I>N</I>-[<I>N</I>-[<I>N</I>-[2, 3-didehydro-<I>N</I>-methyl-<I>N</I>-[<I>N</I>-[3-(2-pentylphenyl)-propionyl]-L-threonyl] tyrosyl-L-Ieucynyl]-D-phenylalanyl]-L-allo-threonyl]-L-asparaginyl]-L-serine-ϒ-lactone} (FK 224) (1 mg/kg), had no effect on tracheal plasma extravasation induced by dextran sulfate and bradykinin. Dextran sulfate (32 mg/kg) with captopril (1 mg/kg) greatly increased the bradykinin level in guinea pig plasma. This evidence suggests that dextran sulfate releases bradykinin in guinea pig plasma and causes guinea pig tracheal plasma extravasation via the activation of bradykinin B<SUB>2</SUB>-receptors.
- 社団法人 日本薬理学会の論文
- 1996-11-01
著者
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Matsuda Atsushi
Department of Cardiology, International Good-will Hospital
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Fujii Takashi
Department Of Cardiology Hiroshima General Hospital
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Morimoto Hiroshi
Department of Pathology, School of Medicine Yamaguchi University
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Morimoto H
Osaka Prefecture Univ. Osaka Jpn
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Ohori Makoto
Department of Urology, Tokyo Medical College
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YAMASHITA Masakatsu
Department of Immunology, Graduate School of Medicine, Chiba University
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MIYAKE Hiroshi
Department of Orthopaedic Surgery, Kagawa Medical Univeristy, Kinashi Ohbayashi Hospital
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Matsuda Atsushi
Department Of Cardiology International Goodwill Hospital
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Matsuda Atsushi
Department Of Pharmacology New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ohori Makoto
Department Of Pharmacology Medical Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ohori Makoto
Department Of Pharmacology New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Morimoto Hiroshi
Department Of Chemistry Kinki University
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Yamashita Masakatsu
Department Of Immunology Graduate School Of Medicine Chiba University
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Yamashita Masakatsu
Department Of Pharmacology
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Fujii Takashi
Department Of Pharmacology New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Miyake Hiroshi
Department Of Biosphere Resources Science Graduate School Of Bioagricultural Sciences Nagoya Univers
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Morimoto Hiroshi
Department Of Chemistry Faculty Of Science Konan University
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Morimoto Hiroshi
Department Of Pharmacology Medical Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Fujii Takashi
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Morimoto Hiroshi
Department Of Pharmacology New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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