Long-Term Outcome of Continuous 3-day Intravesical Instillation Therapy with Bleomycin for Prophylaxis of Superficial Bladder Cancer Recurrence : A Comparative Study
スポンサーリンク
概要
- 論文の詳細を見る
Intravesical bleomycin (BLM) instillation was conducted on 48 cases of superficial (Ta and T1) bladder cancer to prevent recurrence following transurethral resection and the results were compared with those of a matched control also comprised of 48 patients. BLM was instillated immediately after transurethral resection of bladder tumors with 120mg/2,000ml saline solution/day for 3 days postoperatively using a 22F three way Foley balloon catheter. Recurrence was noted in 24 patients (50.0%) in the BLM group and 35 (72.9%) in the control. Recurrence rate per 100 patient-months was significantly reduced in the former (1.08), compared to the latter (1.97). The mean interval to first recurrence was significantly greater in the BLM group. Disease-free intervals in the two groups were 52.2% and 30.9% at 5 years, 29.4% and 21.2%, respectively, at 10 years, with statistically differences evident for the BLM and control (p=0.0117, log rank test). No local or systemic side effects were seen. Intravesical BLM instillation thus appears an effective means for preventing bladder tumor recurrence after resection.
- 北里大学の論文
- 1996-08-31
著者
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Kohno K
Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Heal
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Kohno Kimitoshi
Department Of Molecular Biology University Of Occupational And Environmental Health School Of Medici
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Koshiba Ken
Department Of Urology Kitasato University School Of Medicine
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Koshiba Ken
Departments Of Urology And Pathology Kitasato University School Of Medicine
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EGAWA Shin
Department of Urology Kitasato University School of Medicine
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UCHIDA Toyoaki
Department of Urology, Tokai University Hachioji Hospital
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Ao Teruaki
Department Of Urology Faculty Of Medicine Kyoto University
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Uchida Toyoaki
Department Of Urology Kitasato University School Of Medicine
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IWAMURA Masatsugu
Department of Urology, Kitasato University School of Medicine
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Iwamura M
Department Of Urology School Of Medicine Kitasato University
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Ohori Makoto
Department of Urology, Tokyo Medical College
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SHIBATA Yuji
Department of Neurosurgery, Hyogo Brain and Heart Center
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EGAWA Shin
Working Group for Creation of Clinical Practice Guidelines for Prostate Cancer
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Shibata Yuji
Department Of Neurosurgery Hyogo Brain And Heart Center
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Shibata Yuji
Department Of Urology Kitasato University School Of Medicine
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Suyama Izuho
Department of Urology, Kitasato University School of Medicine
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Egawa Shin
Department Of Urology Jikei University School Of Medicine
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Egawa Shin
Department Of Urology School Of Medicine Kitasato University
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Egawa Shin
Graduate Student Tohoku University
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Koshiba K
Tokyo Metropolitan Hachioji Children's Hospital
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Terai Akito
Department Of Urology Kyoto University Graduate School Of Medicine
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Suyama Izuho
Department Of Urology Kitasato University School Of Medicine
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Ohori Makoto
Department Of Urology Iwate Medical University
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Ohori Makoto
Department Of Pharmacology Medical Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Iwamura Masatsugu
Department Of Urology Kitasato University Hospital
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Ohori Makoto
Department Of Urology School Of Medicine Kitasato University
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Eta Shin-ichi
Department Of Urology Kagoshima University Faculty Of Medicine
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Kondo Katsuyoshi
Department Of Urology Okayama Red Cross General Hospital
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Egawa Shin
Departments Of Urology Kitasa To University School Of Medicine
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Koshiba Ken
Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Health
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Uchida Toyoaki
Department of Chemistry, Faculty of Science, Hokkaido University
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