The Cannabinoid Receptor Agonist WIN 55212-2 Inhibits Neurogenic Inflammations in Airway Tissues
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概要
- 論文の詳細を見る
We examined the effects of a cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2), on various respiratory reactions induced by the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). WIN 55212-2 significantly inhibited capsaicin-induced guinea pig bronchoconstriction, but not the neurokinin A-induced reaction. Intravenous injection of WIN 55212-2 also blocked cigarette smoke-induced rat tracheal plasma extravasation. However, substance P-induced rat tracheal plasma extravasation was not affected by the administration of WIN 55212-2. A cannabinoid CB2 receptor antagonist, {N-[(1S)-endo-1,3,3-trimethylbicyclo[2.2.1] heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide} (SR 144528) reduced the inhibitory effects of WIN 55212-2, but not a cannabinoid CB1 antagonist, [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidehydrochloride] (SR 141716A). A Maxi-K+ channel opener, 1-(2-hydroxy-5-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)benzimidazolone (NS 1619), specifically inhibited capsaicin-induced guinea pig bronchoconstriction and cigarette smoke-induced rat tracheal plasma extravasation. These findings suggest that WIN 55212-2 inhibits the activation of C-fibers via cannabinoid CB2 receptors and Maxi-K+ channels and reduces airway neurogenic inflammatory reactions in vivo.
- 社団法人 日本薬理学会の論文
- 2005-05-20
著者
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ABE TOSHIO
Department of Urology, Aichi Medical University School of Medicine
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Morimoto Hiroshi
Department of Pathology, School of Medicine Yamaguchi University
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Morimoto H
Osaka Prefecture Univ. Osaka Jpn
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Arisaka O
Department Of Pediatrics Dokkyo Medical University School Of Medicine
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Arisaka Osamu
Dep. Of Pediatrics Dokkyo Medical Univ.
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Arisaka Osamu
Department Of Pediatrics Dokkyo University School Of Medicine
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Ohori Makoto
Department of Urology, Tokyo Medical College
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YOSHIHARA Shigemi
Department of Pediatrics, Dokkyo University School of Medicine
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YAMADA Yumi
Department of Pediatrics, Dokkyo University School of Medicine
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Abe Toshio
Department Of Internal Medicine Kanazawa Municipal Hospital
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Ohori Makoto
Department Of Pharmacology Medical Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ohori Makoto
Department Of Pharmacology New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Yoshihara Shigemi
Department Of Pediatrics Dokkyo University School Of Medicine
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Arisaka Osamu
Department Of Pediatrics 1 Neurosurgery 2 And Radiology 3 Dokkyo Medical University School Of Medici
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Yamada Yumi
Department Of Pediatrics Dokkyo University School Of Medicine
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Morimoto Hiroshi
Department Of Chemistry Kinki University
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Abe Toshio
Department Of Cardiovascular Surgery Japanese Red Cross Nagoya First Hospital
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Morimoto Hiroshi
Department Of Chemistry Faculty Of Science Konan University
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Morimoto Hiroshi
Department Of Pharmacology Medical Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Arisaka Osamu
Department of Pediatrics, Dokkyo Medical University, School of Medicine
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Arisaka Osamu
Department of Pediatrics ,Dokkyo Medical University School of Medicine
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ABE Toshio
Department of Pediatrics, Dokkyo University School of Medicine
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YAMASHIRO Yuichiro
Department of Pediatrics, Dokkyo University School of Medicine
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YAMADA Yumi
Department of Nuclear Engineering, Tokyo Institute of Technology
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