Comparative Study of Skin Permeation Profiles between Brand and Generic Tulobuterol Patches
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概要
- 論文の詳細を見る
Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β2-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaired, we compared the skin penetration profiles of the brand and generic patches using a skin barrier-impaired rat model. Skin penetration was significantly (p<0.001) higher in the generic patches compared with the brand patch, suggesting that it is important to understand the pharmaceutical properties of available products by giving careful consideration not only to the patients asthma control but also to their skin condition before using tulobuterol patches.
- 日本薬学会の論文
著者
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ABE TOSHIO
Department of Urology, Aichi Medical University School of Medicine
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Arisaka Osamu
Department Of Pediatrics Dokkyo University School Of Medicine
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YOSHIHARA Shigemi
Department of Pediatrics, Dokkyo University School of Medicine
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Fukuda Hironobu
Department of Pediatrics, Dokkyo Medical University
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Abe Toshio
Department Of Internal Medicine Kanazawa Municipal Hospital
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Yoshihara Shigemi
Department Of Pediatrics Dokkyo University School Of Medicine
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Arisaka Osamu
Department Of Pediatrics 1 Neurosurgery 2 And Radiology 3 Dokkyo Medical University School Of Medici
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Abe Toshio
Department Of Cardiovascular Surgery Japanese Red Cross Nagoya First Hospital
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Arisaka Osamu
Department of Pediatrics ,Dokkyo Medical University School of Medicine
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