Quantitative Measurement of the Ability of Human Chromophobe Adenomas to Synthesize and Release Human Growth Hormone
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概要
- 論文の詳細を見る
Two endocrine functions, HGH syntheses and release, were separately studied on human chromophobe adenomas, isolating the hormone with polyacrylamide gel disc electrophoresis after in vitro labeling of the hormone with 14_C-leucine. The results of the experiments utilizing fresh adenoma tissues obtained from 8 cases at operation revealed that all of the adenomas synthesized and released HGH. Employing appropriate parameters, HGH synthesis and release functions of the tumor were estimated, HGH synthesis function was likely to be extremely low, but the release function rather high. HGH content in the adenoma tissues ranged from 0.04 to 2.56 ng/mg wet tissue, which was exceedingly smaller than the value of 8000 ng/mg wet tissue observed with the human anterior pituitary obtained at autopsy.
- 社団法人日本脳神経外科学会の論文
著者
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Fujii Takashi
Department Of Cardiology Hiroshima General Hospital
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YAMAMOTO Kiyoshi
Departments of Neurosurgery, Niigaita Prefectural Koide Hospital
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Takeda Fumikazu
Department Of Neurosurgery School Of Medicine And Department Of Physiology Institute Of Endocrinolog
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Takeda Fumikazu
Department Of Neurosurgery Saitama Cancer Center
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SASAKI Ryohzoh
Department of Neurosurgery, School of Medicine, and Department of Physiology, Institute of Endocrino
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MISUMI Shuhzoh
Department of Neurosurgery, School of Medicine, and Department of Physiology, Institute of Endocrino
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Misumi Shuhzoh
Department Of Neurosurgery School Of Medicine And Department Of Physiology Institute Of Endocrinolog
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Sasaki Ryohzoh
Department Of Neurosurgery School Of Medicine And Department Of Physiology Institute Of Endocrinolog
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Fujii Takashi
Department Of Neurosurgery School Of Medicine And Department Of Physiology Institute Of Endocrinolog
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Fujii Takashi
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Yamamoto Kiyoshi
Department Of Neurosurgery School Of Medicine And Department Of Physiology Institute Of Endocrinolog
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Yamamoto Kiyoshi
Department Of Neurosurgery Niigata Rosai Hospital:m.d. Department Of Neurosurgery Nagaoka Red Crossh
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