The Profile of FR140423, a Novel Anti-inflammatory Compound, in Yeast-Induced Rat Hyperalgesia
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism of action of FR140423 (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole), a novel anti-inflammatory compound, in a rat yeast-induced hyperalgesic model was investigated and compared with those of indomethacin and morphine. We tested the inhibitory effects of FR140423 on the formation of arachidonic acid metabolites, prostaglandin (PG) E2, thromboxane (TX) B2 and leukotriene (LT) B4, in yeast-injected inflamed paws and the effect of the opioid receptor antagonist naloxone on FR140423-induced anti-hyperalgesic effect and inhibition of the formation of arachidonic acid metabolites. Oral administration of FR140423 showed a dose-dependent anti-hyperalgesic effect. This effect was fourfold more potent than that of indomethacin but less potent than that of morphine. Unlike morphine, FR140423 suppressed the levels of PGE2 and TXB2 but not LTB4 in inflamed paws. FR140423 did not inhibit yeast-induced paw edema. The anti-hyperalgesic effect of FR140423 in yeast-injected rat paws was partially blocked by naloxone. However, the inhibitory effects of FR140423 on the formation of PGE2 and TXB2 in yeast-injected rat paws were not antagonized by naloxone. These results suggest that FR140423 shows a potent anti-hyperalgesic effect mediated by inhibition of PGs in inflamed tissue and by activation of opioid receptors.
- 社団法人 日本薬理学会の論文
著者
-
Fujii Takashi
Department Of Cardiology Hiroshima General Hospital
-
GOTO Toshio
Department of Quantum Engineering, Nagoya University
-
Ochi Takehiro
Department Of Immunology And Inflammation Medicinal Biology Research Laboratories Fujisawa Pharmaceu
-
Ochi Takehiro
Department Of Electronic Chemistry Tokyo Institute Of Technology
-
Goto Toshio
Department Of Electronics Faculty Of Engineering Nagoya University
-
MOTOYAMA Yukio
Department of Immunology and Inflammation, Medicinal Biology Research Laboratories, Fujisawa Pharmac
-
Motoyama Yukio
Department Of Immunology And Inflammation Medicinal Biology Research Laboratories Fujisawa Pharmaceu
-
Goto Toshio
Department Of Electronic Mechanical Engineering Nagoya University
-
Goto Toshio
Department Of Immunology And Inflammation Medicinal Biology Research Laboratories Fujisawa Pharmaceu
-
Fujii Takashi
Department Of Applied Physics And Chemistry The University Of Electro-communications
-
Fujii Takashi
Department Of Immunology And Inflammation Medicinal Biology Research Laboratories Fujisawa Pharmaceu
-
GOTO Toshio
Department of Agricultural Chemistry, Faculty of Agriculture, Nagoya University
関連論文
- PE-234 Evaluation of the Effect of Valsartan on Target Lesion Revascularization after Percutaneous Coronary Intervention(PE040,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- Angiotensin-Converting-Enzyme Inhibitor Quinapril Improves Long-Term Prognosis after Coronary Intervention
- Prevalence, Distribution and Their Determinants of Calcification in Left Anterior Descending Coronary Artery : An 3-D Intravascular Ultrasound Study
- PJ-564 Reduction of In-stent Restenosis by Undersized Stenting : A Study with Quantitative Coronary Analysis(Restenosis after Angioplasty, Basic/Clinical 6 (IHD) : PJ94)(Poster Session (Japanese))
- PJ-134 Does ARB Valsartan Reduce Cardiac Events after Coronary Stenting? : Results of the Coronary Atherosclerosis Reduction Project (CARP) at 1-Year follow-up(Restenosis basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- Longitudinal Assessment of Atherosclerotic Plaque Rupture with Computer-Simulated Color-Mapping of Plaque Stress Distributionand Intravascular Ultrasound Imaging
- Assessment and Prediction of Coronary Atherosclerotic Plaque Rupture by Longitudinal Intravascular Ultrasound Imaging and Computer-Simulated Color-Mapping of Plaque Stress Distribution
- Negative Ion Assisted Silicon Oxidation in Downstream of Microwave Plasma
- Growth of Carbon Nanotubes by Microwave-excited Non-Equilibrium Atmospheric-Pressure Plasma
- Diamond Film Formation by OH Radical Injection from Remote Microwave H_2/H_2O Plasma into Parallel-Plate RF Methanol Plasma
- High-Rate Anisotropic Ablation and Deposition of Polytetrafluoroethylene Using Synchrotron Radiation Process
- Synthesis of Diamond Using RF Magnetron Methanol Plasma Chemical Vapor Deposition Assisted by Hydrogen Radical Injection
- Importance of NAD(P)H Oxidase-Mediated Oxidative Stress and Contractile Type Smooth Muscle Myosin Heavy Chain at the Early Stage of Atherosclerosis
- Anti-inflammatory Action of Antioxidant Probucol on Vascular Smooth Muscle Cells in Hyperlipidemic Rabbit Aorta
- OJ-016 Primary Studies of ECG-Triggered Non-Gated High-Pitch Helical Cardiac Scanning Using 40mm Coverage Volume CT(CT/DSA-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-275 Evaluation of Coronary Artery Bypass Grafts' Patency and Distal Anastomoses Assessed by 16-detector Row Computed Tomography(X-ray/CT/MRI/DSA5 (I) : PJ46)(Poster Session (Japanese))
- PJ-264 Assessment of Coronary Artery Stenoses With 16-slice Multidetector-Row Helical Computed Tomography (MDCT) : Diagnostic Accuracy in Comparison to Coronary Angiography(X-ray/CT/MRI/DSA3 (I) : PJ44)(Poster Session (Japanese))
- PJ-261 Coronary Arteries Visualization by 16-slice Multidetector-Row Helical Computed Tomography (MDCT)(X-ray/CT/MRI/DSA3 (I) : PJ44)(Poster Session (Japanese))
- Study on the Absolute Density and Translational Temperature of Si Atoms in Very High Frequency Capacitively Coupled SiH_4 Plasma with Ar, N_2, and H_2 Dilution Gases
- Effects of Ar Dilution and Exciting Frequency on Absolute Density and Translational Temperature of Si Atom in Very High Frequency-Capacitively Coupled SiH_4 Plasmas
- Effects of Driving Frequency on the Translational Temperature and Absolute Density of Si Atoms in Very High Frequency Capacitively Coupled SiF_4 Plasmas
- PE-065 Sixty-four-slice CT Angiography has been Replacing Invasive Coronary Angiography : A Survey on Cardiac CT in Hiroshima Prefecture(CT/DSA(04)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Definitive intraoperative radiotherapy for musculoskeletal sarcomas and malignant lymphoma in combination with surgical excision
- Survival prediction using artificial neural networks in patients with uterine cervical cancer treated by radiation therapy alone
- Successful Thermoradiotherapy in Recurrent Mucosal Melanoma of the Nasal Cavity and Paranasal Sinus : Report of Three Cases
- Histopathological prognostic factors in patients with cervical cancer treated with radical hysterectomy and postoperative radiotherapy
- Enhancement of Negative-Ion-Assisted Silicon Oxidation by Radio-Frequency Bias
- PE-473 Effects of Air Pollutants on Emergency Admissions due to Heart Disease in Ube(Preventive medicine/Epidemiology/Education(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Thallium-201 SPECT in prognostic assessment of malignant gliomas treated with postoperative radiotherapy
- Thallium-201 scintigraphy in bone and soft-tissue tumors : a comparison of dynamic, early and delayed scans
- Assessment of liver function in chronic liver diseases and regional function of irradiated liver by means of ^Tc-galactosyl-human serum albumin liver scintigraphy and guantitative spectral analysis
- Ventricular Conduction in Idiopathic Ventricular Fibrillation without Right Precordial ST Elevation : Comparative Study with Brugada Syndrome
- H_2 Partial Pressure Dependences of CH_3 Radical Density and Effects of H_2 Dilution on Carbon Thin-Film Formation in RF Discharge CH_4 Plasma
- Correlation between CH_3 Radical Density and Carbon Thin-Film Formation in RF Discharge CH_4 Plasma
- Calculated Three Dimensional Spatial Distribution of CH_3 Radical Density in the RF Discharge CH_4 Plasma with Parallel-Plate Electrodes
- Effect of Rare Gas Dilution on CH_3 Radical Density in RF-Discharge CH_4 Plasma
- Dynamic Determinants of Left Ventricular Early Diastolic Filling in Old Myocardial Infarction : CLINICAL EVALUATION OF CARDIAC PERFORMANCE
- GLOBAL AND REGIONAL DIASTOLIC FILLING DYNAMICS IN COMPENSATED DILATED CARDIOMYOPATHY : The 53th Annual Scientific Session of the Japanese Circulation Society
- PJ-055 Relation between High Molecular Adiponectin Levels and Characterization of Non-Calcified Coronary Plaque with Color Code Plaque^(PJ009,CT/MRI (Coronary/Vascular) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- OJ-033 Quantitative Assessments of In-stent Lumen by an Experimental Fine-cell Detector CT (FDCT) : Phantom Study in Comparison with 64-row MDCT(OJ06,CT/MRI (Coronary/Vascular) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Jap
- OJ-031 Assessment of Coronary Plaque CT Value Influence by Intracoronary Contrast Media Using the Coronary Stenosis Phantom on 64-row MDCT(OJ06,CT/MRI (Coronary/Vascular) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-465 Usefulness of 64-Slice Computed Tomography to Diagnose Coronary In-Stent Restenosis(CT/DSA(09)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-071 Relationship between Non-Calcified Plaque Characterization by Color Code Plaque^ with MDCT and Plasma High Molecular Adiponectin Levels in Men(CT/DSA(07)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- PJ-068 Accuracy of Color Code Plaque^ With 64-multislice Computed Tomography for Characterizing Coronary Plaque, and Comparison With Integrated Backscatter Intravascular Ultrasound(CT/DSA(07)(I),Poster Session(Japanese),The 72nd Annual Scientific Meet
- OJ-192 Primary Evaluation of Novel Prospective ECG Gated Non-Helical Cardiac Scan (Snap Shot Pulse^)on 64-row MDCT(CT/DSA(03)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Improved Performance of Discharge-Pumped XeCl Laser Using Ar/He Diluent
- High Performance of Silicon Oxide Selective Etching Using F_2 Gas and Graphite Instead of Perfluorinated Compound Gases
- Diamond Deposition and Behavior of Atomic Carbon Species in a Low-Pressure Inductively Coupled Plasma
- Behaviors of carbon atom density in hydrocarbon and fluorocarbon plasmas
- Measurement of Einstein's A Coefficient of the 296.7 nm Transition Line of the Carbon Atom
- Measurement of Carbon Atom Density in High Density Plasma Process
- Electrophysiological and Biochemical Effects of Exposure to 2, 5-Hexanedione on Peripheral Nerve in Experimental Diabetic Rats
- Echocardiographic Predictors of Remote Outcome in Patients With Angiographically Successful Reflow After Acute Myocardial Infarction
- Fabrication of Multilayered SiOCH Films with Low Dielectric Constant Employing Layer-by-Layer Process of Plasma Enhanced Chemical Vapor Deposition and Oxidation
- Effects of Oxygen and Nitrogen Atoms on SiOCH Film Etching in Ultrahigh-Frequency Plasma
- Plasma Induced Subsurface Reactions for Anisotropic Etching of Organic Low Dielectric Film Employing N_2 and H_2 Gas Chemistry
- Synthesis of Polytetrafluoroethylene-like Films by a Novel Plasma Enhanced Chemical Vapor Deposition Employing Solid Material Evaporation Technique
- Vascular Endothelial Growth Factor (VEGF) and Bone Morphogenetic Protein-4 (BMP-4) in Endochondral Ossification from Grafted Periosteum
- Coronary Plaque Stabilization Followed by Color Code Plaque^ Analysis With 64-Slice Multidetector Row Computed Tomography
- P3-07 Immunohistochemical study of BMP-2 and -4 in endochondral ossification from grafted periosteum
- Electron Energy Control in Inductively Coupled Plasma Employing Multimode Antenna
- CH_3 Radical Density in Electron Cyclotron Resonance CH_3OH and CH_3OH/H_2 Plasmas
- CW Laser-Induced Fluorescence Study of SiH_2+ SiH_4 Reaction : Dominance of Two-Body Reaction Channel in Low-Pressure Silane Plasma
- Translational Temperature Measurement for SiH_2 in RF Silane Plasma Using CW Laser Induced Fluorescence Spectroscopy
- Laser-Induced-Fluorescence Study of SiH2 in a RF SiH4/SiH2Cl2 Plasma (レ-ザ-および放射光の半導体プロセス分野への応用特集号)
- Evaluation of CF_2 Radical as a Precursor for Fluorocarbon Film Formation in Highly Selective SiO_2 Etching Process Using Radical Injection Technique
- CF_X (X=1-3) Radical Measurements in ECR Etching Plasma Employing C_4F_8 Gas by Infrared Diode Laser Absorption Spectroscopy
- Characteristics of Fluorocarbon Radicals and CHF_3 Molecule in CHF_3 Electron Cyclotron Resonance Downstream Plasma
- CF_X(X=1-3) Radicals Controlled by On-Off Modulated Electron Cyclotron Resonance Plasma and Their Effects on Polymer Film Deposition ( Plasma Processing)
- Generation of Squeezed Vacuum Using Wavelength-Tunable Soliton Pulse and Nonlinear Polarization Interferometer
- Generation of Squeezed Vacuum using Spectral Filter by Spatial Light Modulator and Nonlinear Polarization Interferometer
- Cleaning of Glass Disk in Oxygen Plasma by Using Compact Electron-Beam-Excited Plasma Source
- Protective Effect of FR168888, a New Na^+/H^+ Exchange Inhibitor, on Ischemia and Reperfusion-Induced Arrhythmia and Myocardial Infarction in Rats : In Comparison With Other Cardioprotective Compounds
- Kinetics of CF_x (x = 1-3) Radicals and Electrons in RF CF_4-H_2, CHF_3-H_2 and CHF_3-O_2 Plasmas
- CF_3, CF_2 and CF Radical Measurements in RF CHF_3 Etching Plasma Using Infrared Diode Laser Absorption Spectroscopy ( Plasma Processing)
- Squeezed Vacuum Generation Using Symmetric Nonlinear Polarization Interferometer : Optics and Quantum Electronics
- Nonlinear Polarization Interferometer for Photon-Number Squeezed Light Generation : Optics and Quantum Electronics
- Analysis of Generation Mechanism of Photon-Number Squeezed Light Using Ultrashort Pulse and Asymmetric Fiber Loop Mirror
- Characteristics of Intensity Noise Reduction of Optical Pulses Using Variabel Spectral Filters and Optical Fibers
- Measurements of the CF Radical in DC Pulsed CF_4/H_2 Discharge Plasma Using Infrared Diode Laser Absorption Spectroscopy
- Spatial Distribution of SiH_3 Radicals in RF Silane Plasma
- SiH_3 Radical Density in Pulsed Silane Plasma
- Diffusion Coefficient and Reaction Rate Constant of the SiH_3 Radical in Silane Plasma
- Measurement of the SiH_3 Radical Density in Silane Plasma using Infrared Diode Laser Absorption Spectroscopy : Techniques, Instrumentations and Measurement
- PJ-066 Middle-Term Outcome after Stenting of Bifurcation Lesions with 'Hybrid Y-Stenting'(Coronary revascularization, PCI(17)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-325 Significance of Lipid-content in Determining the Pattern of Coronary Arterial Remodeling : An Intravascular Ultrasound Study by Use of Wavelet Analysis(Atherosclerosis, clinical-10 (H) PJ55,Poster Session (Japanese),The 70th Anniversary Annual Scie
- PJ-229 Dual-frequency intravascular ultrasound imaging : A Novel Approach to Plaque Vulnerability(Intravascular endoscopy/Intravascular ultrasound-5 (I) PJ39,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulat
- Measurement of Spatial Distribution of SiF_4 and SiF_2 Densities in High Density SiF_4 Plasma Using Single-Path Infrared Diode Laser Absorption Spectroscopy and Laser-Induced Fluorescence Technique
- Quality of life after neck dissection : a multicenter longitudinal study by the Japanese Clinical Study Group on Standardization of Treatment for Lymph Node Metastasis of Head and Neck Cancer
- 1 Comprehensive Approach for Identifying Vulnerable Coronary Plaques with Use of Intravascular Ultrasound(New Horizon in Coronary Interventions for Acute Coronary Syndrome, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Characterization of Dextran Sulfate-Induced Guinea Pig Tracheal Plasma Extravasation
- Effects of ω-Conotoxin GVIA on the Activation of Capsaicin-Sensitive Afferent Sensory Nerves in Guinea Pig Airway Tissues
- Preparation of New Nitrogen-Bridged Heterocycles. 40. Synthesis of 1,4-Dihydropyrido[2,3-b] indolizin-4-one Derivatives
- The Profile of FR140423, a Novel Anti-inflammatory Compound, in Yeast-Induced Rat Hyperalgesia
- Bio-inspired Materials for Electron Donors and Charge-transfer Complex Formation Based on the Imidazopyrazinone Luciferin Core
- Relation between Ge(2) Center and 11.9 mT Hyperfine Structure of ESR Spectra in Ge-Doped Silica Fibers : Magnetism, Magnetic Materials and Devices
- The 1.52μm Absorption Band in Optical Fibers Induced by Hydrogen Treatment
- Quantitative Measurement of the Ability of Human Chromophobe Adenomas to Synthesize and Release Human Growth Hormone
- A case of cardiac rupture subsequent to myocardial infarction diagnosed in emergency room
- PJ-676 Evaluation of Coronary Various Artery Stents of Different Material and Size with 16-slice MDCT : Basic Assessment Using Pulsating Cardiac Phantom(CT/DSA-8 (I) PJ114,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Jap