Tissue Concentrations of Chlordanes in Mice after Long-term Exposures to Technical Grade Chlordane at Indoor Air Levels

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概要

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• We determined concentrations of chlordanes (5 chlordane compounds and 2 metabolites) in tissues and organs of mice following a prolonged exposure to Chlordane (technical grade chlordane) at levels as low as those in indoor air. After exposure to 4.22-11.36μg/m^3 Chlordane (total of 5 compounds) in the air for 1-6 months, 6.44-13.00 ppm chlordanes (total of 7 compounds) were detected in mice (2 tissues and 6 organs). The adipose tissue among the 2 tissues / 6 organs examined contained the highest chlordanes. The ratio of the adipose tissue chlordanes to the liver chlordanes was approximately 5.6 times, followed by the muscle (0.9), lungs (0.4), kidneys (0.4), heart (0.3), spleen (0.2) and brain (0.1). In addition, trans-nonachlor, oxychlordane and heptachlorepoxide in chlordanes were at a high level. The level of Chlordane exposure (dose) and the level of chlordanes accumulation in each tissue or organ of the mice except for the heart were closely correlated (r=0.9388-0.7130), and showed a linear relationship. The tendency of chlordanes accumulation in light of the linear relationship was adipose≫liver≧muscle. Thus, even with a low level of Chlordane in indoor air, chlordanes may be steadily accumulated in the bodies of human residents with prolonged exposure similarly. The present findings suggest that it is necessary to investigate the risk of organochlorine chemicals contamination in indoor air at prolonged exposure.

• 日本衛生学会の論文

著者

• JITSUNARI Fumihiko

  Department of Hygiene & Public Health, Faculty of Medicine, Kagawa Medical University

• SUNA Shigeru

  Department of Hygiene & Public Health, Faculty of Medicine, Kagawa Medical University

• FUKUNAGA Ichiro

  Department of Hygiene & Public Health, Factulty of Medicine, Kagawa Medical University

• TAKEDA Noriaki

  Department of Medical Systems Management, Faculty of Medicine, Kagawa Medical University

• CHOI Jin

  Department of Earth and Environmental Sciences, Gyeongsang National University

• Choi Jin

  Department Of Biochemistry School Of Medicine Kyungpook National University

• Takeda Noriaki

  Department Of Medical Systems Management School Of Medicine Kagawa Medical University

• SHIRAISHI Hiroaki

  National Institute for Environmental Studies

• Fukunaga Ichiro

  Department Of Hygiene And Public Health School Of Medicine Kagawa Medical University

• Yoshihara Kenji

  Department of Life Science, Faculty of Agriculture, Kagawa University

• SHIRAISHI Hiroaki

  Department of Pharmacology, Fujita Health University School of Medicine

• Jitsunari Fumihiko

  Kagawa Univ. Kagawa Jpn

• Choi Jinok

  Department Of Hygiene And Public Health School Of Medicine Kagawa Medical University

• ASAKAWA Fumiyuki

  Department of Hygiene and Public Health, School of Medicine, Kagawa Medical University

• Takeda Noriaki

  Department Of Medical Social Work Faculty Of Medical Welfare Kawasaki University Of Medical Welfare

• Yoshihara K

  Department Of Hygiene And Public Health School Of Medicine Kagawa Medical University

• Yoshihara Kenji

  Department Of Hygiene And Public Health School Of Medicine Kagawa Medical University

• Shiraishi Hiroaki

  Department Of Chemical Engineering & Technology Faculty Of Engineering Kyushu University

• Choi Jin

  Department Of Biochemistry And Cell Biology School Of Medicine Kyungpook National University

• Choi Jin

  Department Of Agricultural Engineering Chonbuk National University

• YOSHIHARA KENJI

  Department of Cbemistry, Faculty of Science, Toboke University,

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