Formation of Chlorinated Derivatives of Bisphenol A in Waste Paper Recycling Plants and Their Estrogenic Activities
スポンサーリンク
概要
- 論文の詳細を見る
High concentrations of bisphenol A were detected in the effluent from several pulping processes for waste paper containing thermal paper and/or other printed paper. Chlorinated derivatives of bisphenol A were found to be formed by its reaction with a low concentration of chlorine in the effluent from the bleaching process using sodium hypochlorite. Poly-chiorinated derivatives were mainly detected in the final effluents from two plants because they were not biodegraded in the water recycling process by treatment with activated sludge. The estrogenic activities of bisphenol A and its chlorinated derivatives were evaluated by an agonist assay using the yeast two-hybrid system with and without a metabolic activation test using rat liver S9. All of the chlorinated derivatives tested showed more potent activity than bisphenol A without S9. The activity of 3,3'-dichlorinated BPA was 38-fold stronger than that of bisphenol A. The activities of these compounds were almost eliminated upon treatment with S9.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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TERAO Yoshiyasu
Institute for Environmental Sciences, University of Shizuoka
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SHIRAISHI Hiroaki
National Institute for Environmental Studies
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Matsushita Hidetsuru
Shizuoka Institute of Environment and Hygiene
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Shiraishi Fujio
National Institute For Environmental Studies
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Terao Yoshiyasu
Institute For Environmental Sciences And Coe Program In The 21th Century University Of Shizuoka
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Fukazawa Hitoshi
Shizuoka Institute of Environment and Hygiene
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Watanabe Masayuki
Shizuoka Institute of Environment and Hygiene
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Shiozawa Tatsushi
Institute for Environmental Sciences, University of Shizuoka
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Shiozawa Tatsushi
Institute For Environmental Sciences And Coe Program In The 21th Century University Of Shizuoka
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Shiraishi Hiroaki
National Institute for Environment Studies
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