Dissolution Properties of Indomethacin from Coprecipitates with Water-Insoluble Glucan(Pharmaceutical)
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概要
- 論文の詳細を見る
The dissolution properties of indomethacin (IMC) from coprecipitates with water-insoluble glucan (WIG) were investigated with a view to application of WIG to pharmaceutical preparations. WIG was produced by an enzyme present in the culture fluid of Streptococcus mutans. Coprecipitates were prepared by evaporation of the solvent from IMC solution in which WIG was suspended. The X-ray diffraction patterns indicated that the size of crystals of IMC was decreased by the coprecipitation. The dissolution rate of IMC from the coprecipitates was significantly greater than that from the physical mixture or intact IMC powder. These results indicate that WIG can improve the dissolution properties of IMC.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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Yoshida Akiyoshi
The Application And Development Division Of Rohto Pharmaceutical Co. Ltd.
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NAGAI Tsuneji
Faculty of Pharmaceutical Sciences, Hoshi University
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Hayashi Shin'ichi
The Research And Development Division Of Rohto Pharmaceutical Co. Ltd.
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Hirayama M
Banyu Pharmaceutical Co. Ltd. Tsukuba Jpn
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MASUMOTO KEN
The Application and Development Division of Rohto Pharmaceutical Co., Ltd.
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HIRAYAMA MASAMI
The Application and Development Division of Rohto Pharmaceutical Co., Ltd.
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MACHIDA YOSHIHARU
Faculty of Pharmaceutical Sciences, Hoshi University
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Masumoto Ken
The Application And Development Division Of Rohto Pharmaceutical Co. Ltd.
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Nagai T
Hoshi Univ. Tokyo Jpn
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Nagai Tsuneji
Faculty Of Pharmaceutical Sciences Hoshi University
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Machida Y
Hoshi Univ. Tokyo Jpn
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Machida Yoshiharu
Faculty Of Pharmaceutical Sciences Hoshi University
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