Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin
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概要
- 論文の詳細を見る
We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos W_<OLF>(Polyporaceae), a well-known traditional Chinese medicinal plant. We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus(NIDDM)and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor γ(PPAR γ)in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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SATO Mayumi
Department of Astronomy, Graduate School of Science, The University of Tokyo
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佐藤 正基
School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation
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Satoh M
Showa Pharmaceutical Univ. Tokyo Jpn
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Sato M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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KAWASHIMA Seiichi
Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science
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Kawashima S
Department Of Molecular Biology Tokyo Metropolitan Institute Of Medical Science
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Kawashima Seiichi
Department Of Molecular Biology Tokyo Metropolitan Institute Of Medical Science
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Kawashima Seiichi
Department Of Molecular Biology Tokyo Metropolitan Institute For Medical Science
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Kawashima Seiichi
Department Of Biochemistry Tokyo Metropolitan Institute Of Gerontology
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Nunoura Yoshiki
Central Research Laboratory, Kotaro Pharmaceutical Co., Ltd.
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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TAI Takaaki
Central Research Laboratory Kotaro Pharmaceutical Co., Ltd.
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YAJIMA Yukiko
Department of Molecular Biology, Tokyo Metropolitan Institute for Medical Science
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TANAKA Keiji
Molecular Oncology, Tokyo Metropolitan Institute for Medical Science
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Tai Takaaki
Central Research Laboratory Kotaro Pharmaceutical Co. Ltd.
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Yajima Yukiko
Department Of Molecular Biology Tokyo Metropolitan Institute For Medical Science
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Yajima Yukiko
Department Of Molecular Biology The Tokyo Metropolitan Institute Of Medical Science
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Nunoura Yoshiki
Central Research Laboratory Kotaro Pharmaceutical Co. Ltd.
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Yajima Yukiko
Department Of Applied Biochemistry Tokai University School Of Engineering
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Tanaka Keiji
Molecular Oncology Tokyo Metropolitan Institute For Medical Science
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Nunoura Yoshiki
Central Research Laboratory Kotaro Pharmaceutical Co., Ltd.
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