銅クロロフィリンナトリウムの脂質過酸化反応におよぼす影響(第3報)市販銅クロロフィリンナトリウムの抗酸化能について

概要

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Several commercial preparations of sodium copper chlorophyllin (Cu-Chl-Na) containing copper chelate compounds of chlorophyll derivatives were examined for their lipid peroxidation inhibitory activities in rat liver homogenates. The inhibitory effect on lipid peroxidation stimulated by both Fe^<2+> and ascorbic acid differed from preparation to preparation. The potency of the antioxidative activity was found to be correlated with the intensity of the absorption maximum at ca. 628 nm, which was assumed to be attributable to the chemical structure of the copper complexes of chlorin derivatives. On the other hand, the sample which did not show any absorption in the red-band region exerted no effect on lipid peroxidation. These results suggest that the Cu-Chl-Na preparation, which contains a larger amount of copper complexes of chlorin derivatives, has more potent antioxidant activity. In addition, sodium iron chlorophyllin also showed inhibitory action on lipid peroxidation in rat liver homogenates, indicating that the antioxidative effect is not specific for Cu-Chl-Na.
公益社団法人日本薬学会の論文
1980-05-25