薬物の胎盤通過と代謝

概要

論文の詳細を見る
Studies on the drug metabolism and transplacental transport were reviewed. When the drug and its phase I metabolite (s) are lipid soluble, they easily cross the placenta, whereas phase II metabolites hardly penetrate the placenta. P-450 and its reductase were found in human placental microsomes, and the metabolism of some hydrocarbons in the placenta of smoking mother was clarified. But the placenta must not be a "metabolic barrier" to most drugs, because drug-metabolizing enzymes may be poorly distributed in this organ. Many studies demonstrated the inability of fetuses of laboratory animals to metabolize drugs. Whereas the human fetuses have drug oxidation capacity which is different from that of fetuses of laboratory animals. It was also shown that the human fetal liver and adrenal glands played a significant role in drug metabolism.
日本医療薬学会の論文
1978-08-20