コイ肝膵臓ライソゾ-ムに及ぼすPCBの影響〔水生生物に及ぼすPCBの影響-10-〕

概要

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Investigation of the action of PCB on the carp hepatopancreas lysosomal membranes was carried out. The results obtained were as follows: The fragility of hepatopancreas of carp 14 days after PCB administration was investigated by exposing the lysosome fraction by freezing and thawing or preincubation at 50°C. In all cases both hydrolase, acid phosphatase and β-glucuronidase were released in greater quantity than in the control specimens. The release of acid phosphatase and β-glucuronidase were induced by the addition of PCB to the lysosome suspension prepared from normal carp hepatopancreas. Sodium copper chlorophyllin, α-tocopherol, lecithin and cortisone inhibited the release of acid phosphatase and β-glucuronidase from the lysosome fraction of carp hepatopancreas in vitro. It was suggested that PCB may induce instability of the lysosomal membrane depending on the lipophilic property.
日本水産學會の論文