銅クロロフィリンナトリウムの脂質過酸化反応におよぼす影響(第4報)銅クロリンの抗酸化作用
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概要
- 論文の詳細を見る
The relationship between the antioxidative action of sodium copper chlorophyllin (Cu-Chl-Na) and its chemical structure was examined. By the aerobic incubation of Cu-Chl-Na in aqueous solution, the spectral absorbances of the solution at Soret (406 nm) and red (632 nm) maxima decreased while the ratio of the absorbances (Soret/red) increased. Since the Cu-Chl-Na incubated aerobically lost its original antioxidative activity, the thiobarbituric acid values in the rat liver homogenates treated with Fe^<2+> and ascorbic acid increased, and a decrease in the reduction of 1,1-diphenyl-2-picrylhydrazyl was observed. Further, Cu-Chl-Na reacted directly with 1,1-diphenyl-2-picrylhydrazyl to decrease the spectral absorbances at both Soret and red maxima and to increase the ratio of the absorbances (Soret/red). Since the spectral absorption in the red-band region is attributable to the absorption of copper chlorin structure, the above results suggest that copper chlorins are responsible for the antioxidative activity of Cu-Chl-Na.
- 公益社団法人日本薬学会の論文
- 1980-09-25
著者
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村田 敏郎
静岡薬科大学
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佐藤 正基
School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation
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Imai K
Univ. Tokyo Tokyo Jpn
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Sato M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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Imai K
Department Of Chemistury Faculty Of Science Tokyo University Of Science
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村田 敏郎
School of Pharmaceutical Science, University of Shizuoka
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佐藤 正基
静岡薬科大学
-
村田 敏郎
School Of Pharmaceutical Science University Of Shizuoka
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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Imai K
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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藤浦 秀人
静岡薬科大学
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今井 公江
静岡薬科大学
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