胃腸ホルモンに関する研究(第1報) : クジラ胃よりガストリンおよびガストロン様物質の分離

概要

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Gastrin (I) and gastrone-like substance (II) were extracted from the mucosa of the third stomach of the finback whale (Balaenoptera physalus L.). I is dialyzable and negative to both Ninhydrin and biuret reactions, but positive to the chlorimino reaction. II is non-dialyzable, negative to Ninhydrin reaction, and positive to both biuret and chlorimino reaction. II contained 6-7% of hexose and 8-9% of amino sugar, and was assumed to be a glycoprotein or some glycoproteins. The gastric secretion was elicited by the intravenous administration of 0.5-10 μg/kg of I in the Schild rats, and the same response was elicited by the subcutaneous administration of 10-100 μg/kg of I in the Heidenhain pouch dogs. The inhibition of gastric secretion was observed by the intravenous doses of more than 60 μg/kg of II in the Shay method using pylorus-ligated rats.
1969-07-25