Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. VIII. Its Effect on Carbon Tetrachloride-Induced Liver Injury in Rats

概要

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The present study was carried out to investigate the effectiveness of sodium copper chlorophyllin (Cu-Chl-Na) as an in vivo lipid antioxidant by examining its effect on CCl_4-induced hepatic injury. Rats received two i.p. injections of Cu-Chl-Na (50 or 100mg/kg) in and 2h prior to CCl_4 administration (1 ml/kg, p.o.). It was found that in the pretreated rats, there was effective depression of both the CCl_4-induced lipid peroxidation in hepatic microsomes and the CCl_4-induced increase of lipid peroxides in whole liver at 0.5 and 24h after the dosing of CCl_4,respectively. Cu-Chl-Na pretreatment also clearly inhibited the elevation of serum levels of glutamic oxaloacetic and glutamic pyruvic transaminases and isocitric dehydrogenase, and the increase in liver triglyceride level caused by CCl_4. In addition, the hepatotoxin-induced decrease of hepatic tryptophan pyrrolase activity was substantially prevented in the rats pretreated with Cu-Chl-Na. Since the CCl_4-induced peroxidation of liver lipids is generally accepted to be involved in the pathogenesis of its hepatotoxicity, the above in vivo antioxidative effect of Cu-Chl-Na is considered to play an important role in its protection of rats against the liver damage produced by CCl_4.
社団法人日本薬学会の論文
1985-08-25