PCB類による甲状腺ホルモンかく乱作用とその作用機構 : 動物種差(日本環境変異原学会第32回大会シンポジウム1「環境物質に対する生体応答の分子機構」)

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In the present study, we investigated the mechanism for the decrease in levels of serum thyroid hormones, especially thyroxine (T_4), by polychlorinated biphenyls (PCBs) such as Kanechlor-500 (KC500), 2, 2', 4', 5, 5'-pentachlorobiphenyl (PentaCB), and 2, 2', 3', 4', 5, 6-hexachlorobiphenyl (HexaCB), and studied species differences among mice, hamsters, rats, and guinea pigs in the PCB effect. Significant decrease in serum total T_4 level by KC500 was observed in all four species. On the other hand, there were differences in the level of decrease of serum total T_4 level by PentaCB and HexaCB. Differences in the level of hepatic methylsulfonyl-PCB metabolites of KC500, PentaCB and HexaCB, which were thought to be associated with the PCB-toxic effects, did not necessarily correlate with the magnitude of decrease in serum total T_4 level. Likewise, the induction of UDP-glucuronosyltransferases (T_4-UDP-GT) toward T_4 by PCB did not necessarily correlate with the decrease in serum T_4 level in the animals used. Further studies on transthyretin (TTR) and serum T_4-transporter suggested that decrease in serum total T_4 level induced by PCB occurred not only by induction of T_4-UDP-GT but also by the alteration of levels of T_4-TTR binding and hepatic T_4-transporter. In addition, species difference in the decrease of serum total T_4 was associated with various PCB-induced total effects, including induction of T_4-UDP-GT, decrease in T_4-TTR binding level, the increase of hepatic thyroid hormone transporter, and other thyroid function correlates.
日本環境変異原学会の論文
2004-09-30

PCB類による甲状腺ホルモンかく乱作用とその作用機構 : 動物種差(日本環境変異原学会第32回大会シンポジウム1「環境物質に対する生体応答の分子機構」)

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