Alteration in Membrane Fluidity of Rat Liver Microsomes and of Liposomes by Protoporphyrin and Its Anti-lipidperoxidative Effect
スポンサーリンク
概要
- 論文の詳細を見る
The effect of protoporphyrin (PP) on membrane fluidity was investigated by electron paramagnetic resonance spectroscopy using doxyl stearate spin probes in relation to the anti-lipidperoxidative effect of PP. PP decreased the membrane fluidity in rat liver microsomes at concentrations above 1 mM and also in phosphatidylcholine (PC)-choesterol (Cho) (100 : 8,a molar basis) liposomes. The lipid peroxidation stimulated by Fe^<2+> and L-ascorbic acid in those membrane preparations was attenuated along with the decrease in membrane fluidity by PP. Similar results were also found in Cho-rich PC (100 : 30 to 100) liposomes having less fluidity. These results suggest that the decrease in the membrane fluidity caused by PP may be involved in the antioxidative action of PP.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
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NISHIKAWA TAICHIRO
Yosanoumi Hospital
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Sato M
School Of Pharmaceutical Sciences University Of Shizuoka:(present Address)marusa Corporation
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AIMOTO TACHIO
Shizuoka College of Pharmacy
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AIMOTO Tachio
Faculty of Pharmaceutical Sciences, Setsunan University
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Sato Masaki
School Of Pharmaceutical Sciences University Of Shizuoka:(present Address)marusa Corporation
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NAKASHIMA Toshiaki
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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SHIMA Toshihide
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KIMURA Ryohei
School of Pharmaceutical Sciences and COE21, University of Shizuoka Medicine
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IMAI Kimie
Faculty of Pharmaceutical Sciences, Setsunan University
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IMAI Kimie
Fac. of Pharm. Sci., Setsunan Univ.
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AIMOTO Tachio
Fac. of Pharm. Sci., Setsunan Univ.
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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Imai Kimie
Fac. Of Pharm. Sci. Setsunan Univ.
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Imai Kimie
Faculty Of Pharmaceutical Sciences Setsunan University
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Kimura Ryohei
School Of Pharmaceutical Sciences University Of Shizuoka
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Aimoto Tachio
Fac. Of Pharm. Sci. Setsunan Univ.
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Aimoto Tachio
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakashima Toshiaki
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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SATO Masaki
the Faculty of Science and Engineering, Chuo University
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Shima Toshihide
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Sato Masaki
The Faculty Of Science And Engineering Chuo University
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