EFFECTS OF NEUROLEPTIC BUTYROPHENONES ON PITUITARYADRENAL ACTIVITY IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of some neuroleptic butyrophenones such as haloperidol, clofluperol, trifluperidol, lenperone, moperone, and floropipamide on pituitary-adrenal activity were studied in rats following a single i.p. administration. All the drugs examined caused a marked increase in the plasma and adrenal corticosterone concentrations. The actions of haloperidol, clofluperol, and trifluperidol were shown to be most potent, while floropipamide was the weakest among them. The stimulatory effect of the drugs on adrenocortical activity was completely inhibited by either dexamethasone pretreatment or hypophysectomy and was shown not to be merely due to a consequence of a drug-induced hypothermia. These results indicate that the release of ACTH from the adenohypophysis is necessary for the drug action.
- 公益社団法人日本薬学会の論文
著者
-
Sato M
School Of Pharmaceutical Sciences University Of Shizuoka:(present Address)marusa Corporation
-
MURATA TOSHIRO
Shizuoka College of Pharmacy
-
SATO MASAKI
Shizuoka College of Pharmacy
-
AIMOTO TACHIO
Shizuoka College of Pharmacy
-
KIMURA RYOHEI
Shizuoka College of Pharmacy
-
KAIDA MORIO
Shizuoka College of Pharmacy
-
SATO MASAHIKO
Shizuoka College of Pharmacy
-
AIMOTO Tachio
Fac. of Pharm. Sci., Setsunan Univ.
-
Kimura Ryohei
School Of Pharmaceutical Sciences University Of Shizuoka
-
Aimoto Tachio
Fac. Of Pharm. Sci. Setsunan Univ.
-
SATO Masaki
the Faculty of Science and Engineering, Chuo University
-
Sato Masaki
The Faculty Of Science And Engineering Chuo University
関連論文
- EFFECT OF ACETAZOLAMIDE ON BARBITURATE-INDUCED SLEEPING TIME IN MICE. III. PHARMACOKINETICS OF SERUM ELIMINATION AND BRAIN DISTRIBUTION
- EFFECT OF ACETAZOLAMIDE ON THE ANTICONVULSANT POTENCY OF SEVERAL ANTIEPILEPTIC DRUGS IN MICE
- EFFECT OF ACETAZOLAMIDE ON THE ANTICONVULSANT POTENCY OF PHENOBARBITAL AND OTHER CONVENTIONAL ANTIEPILEPTIC DRUGS IN MICE
- EFFECT OF ACETAZOLAMIDE ON SLEEPING TIME INDUCED WITH BARBITURATES IN MICE : POSSIBLE RELATIONSHIP BETWEEN BARBITURATE SLEEP AND BRAIN CARBONIC ANHYDRASE ACTIVITY
- Alteration in Membrane Fluidity of Rat Liver Microsomes and of Liposomes by Protoporphyrin and Its Anti-lipidperoxidative Effect
- Antioxidative Effect of Protoporphyrin on Lipid Peroxidation in Tissue Homogenates of Intravenously Administered Rats
- ROLE OF THE METHYL SULFONE-CONTAINING METABOLITES IN ALTERATIONS OF HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES BY CHLORINATED BENZENES
- IDENTIFICATION OF SULFUR-CONTAINING METABILITES OF m-DICHLOROBENZENE AND THEIR DISPOSITION AND RELATIONSHIP WITH GLUTATHIONE IN RATS
- INDUCTION OF HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES BY SULFUR-CONTAINING METABOLITES OF DICHLOROBENZENES IN RATS
- EFFECTS OF NEUROLEPTIC BUTYROPHENONES ON PITUITARYADRENAL ACTIVITY IN RATS
- IDENTIFICATION OF SULFUR-CONTAINING METABOLITES OF p-DICHLOROBENZENE AND THEIR DISPOSITION IN RATS
- P7-52 Mechanistic study for the decrease in serum thyroid hormone level in PCB-treated mice(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-14 Species difference among mice, hamsters, rats, and guinea pigs in phenobarbital-induced alteration of serum thyroid hormone level(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proc
- Species difference among mice, hamsters, rats, and guinea pigs in 2,2',4',5,5'-pentachlorobiphenyl or 2,2',3',4',5,6-hexachlorobiphenyl-induced alteration of serum thyroid hormone level (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedi
- Species difference among mice, hamsters, rats, and guinea pigs in Kanechlor-500-induced alteration of serum thyroid hormone level (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Relation between the increase in hepatic UDP- GT and the decrease in serum thyroxine level in Kanechlor-500-treated rats.(GENERAL SESSION BY ORAL PRESENTATION)(ENDOCRINE SYSTEM)
- The induction of hepatic microsomal UDP-glu-curonosyltransferase by the methylsulfonyl metabolites of 2,2',4',5-tetrabromobiphenyl in rats.(GENERAL SESSION BY ORAL PRESENTATION)(ENDOCRINE SYSTEM)
- O12-15 Effects of 2, 2', 4', 5, 5'-Pentachlorobiphenyl and 2, 2', 3', 4', 5, 6-Hexachlorobiphenyl on Serum Hormone Levels in Rats and Mice
- O12-13 Reduction of Serum Thyroxine Concentration by Methylsulfonyl Metabolites of Chlorobenzenes in Male Rats
- O-33 In Vivo Metabolism of 2, 2', 4', 5, 5'-Pentachlorobiphenyl and Its Inductive Activity of Drug-Metabolizing Enzymes : Species Difference between Rats and Mice(Proceedings of the 27th Annual Meeting)
- O-32 2, 2', 4', 5-Tetrabromobiphenyl Metabolite, 3-MeSO_2-2, 2', 4', 5-Tetrabromobiphenyl is a Potent Inducer of CYP2B1/2.(Proceedings of the 27th Annual Meeting)
- Contribution of the 3-Methylsulfonyl Metabolite of 2,2', 4,5,5'-Pentachlorobiphenyl to Heme Metabolic Enzyme Induction by the Parent Compound in Rat Liver(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Reduction of Thyroid Hormone Levels by Methylsulfonyl Metabolites of PCB Congeners in Rats(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Tissue Distribution of Methylsulfonyl Metabolites Derived from 2,2', 4,4'-, 3,3', 4,4'-and 2,3', 4', 5-Tetrachlorobiphenyls in Rats (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Induction of Hepatic Microsomal Drug-Metabolizing Enzymes by 3-Methylsulfonyl-2,2', 4', 5,5'-Pentachlorobiphenyl in Female Rats (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Evidence That 3-Methylsulfonyl Metabolite of 2,2', 4,5,5'-Pentachlorobiphenyl Is Causative Substance of Induction of Hepatic Microsomal Drug-Metabolizing Enzymes by the Parent Compound in Rats (Proceedings of the 23rd Symposium on Toxicology and Environme
- In Vivo Metabolism of Mono-Ortho Substituted Polychlorinated Biphenyls : Identification of Hydroxy and Methylsulfonyl Metabolites with Tissue Retention in Rats (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- In vivo Metabolism of 3,3', 4,4'-Tetrachlorobiphenyl in Rats : Occurrence and Liver-Specific Retention of Methylsulfonyl Metabolite (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Effects of Methylsulfonyl Metabolites of PCBs Accumulated in Tissues of Mammals on Activities of Hepatic Microsomal Drug-Metabolizing Enzymes in Rats (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Nasal Absorption of Digoxin in Rats
- Effects of Chlorobenzenes and Their Methyl Sulfone Metabolites on Microsomal Enzymes Associated with Drug Metabolism in Rat Liver
- Effects of Sulfur-Containing Metabolites of Hexachlorobenzene on the Heme Metabolic Enzymes in Rat Liver
- BILIARY METABOLITES OF m-DICHLOROBENZENE IN RATS
- An Efficient Algorithm for Finding All DC Solutions of Piecewise-Linear Circuits(Regular Section)
- EFFECT OF ACETAZOLAMIDE ON THE ANTICONVULSANT POTENCY OF PHENOBARBITAL IN MICE
- DEVELOPMENT OF TOLERANCE TO THE STIMULATORY EFFECT OF NEUROLEPTIC BUTYROPHENONES ON PITUITARY-ADRENAL ACTIVITY IN RATS
- Studies on the Influence of PCB on Aquatic Organisms. VII. The Effect of Oral Administration of PCB on the Lipid Metabolism of the Carp