IDENTIFICATION OF SULFUR-CONTAINING METABOLITES OF p-DICHLOROBENZENE AND THEIR DISPOSITION IN RATS
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概要
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The structure of two sulfur-containing metabolites of p-dichlorobenzene (p-DCB), the distribution of p-DCB and the metabolites in the blood and some tissues, and the excretion of the metabolites in the urine and feces of rats were studied. After the oral administration of p-DCB, two metabolites emerged in the blood. And these metabolites were found for many hours even after p-DCB had almost disappeared from the blood. It was concluded by comparison of spectral data, thin layer chromatogram and gas chromatogram with those of authentic samples, that the metabolites, M-1 and M-2,are 2,5-dichlorophenyl methyl sulfoxide and 2,5-dichlorophenyl methyl sulfone, respectively. The concentration of M-1 in the blood was higher than that of M-2 for 12 hr after dosing p-DCB, but the blood level of M-2 prevailed thereafter, and maintained an appreciable level even after 120 hr. The storage of p-DCB in the adipose tissue and the slow excretion rates of M-1 and M-2 may be responsible for the existence of the metabolites in the blood for long hours. The highest concentration of M-1 was found in the kidney and that of M-2 was in the blood for the period observed. The excretion of M-1 and M-2 in the urine was much less than that of 2,5-dichlorophenol, the major metabolite.
- 公益社団法人日本薬学会の論文
著者
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Sato M
School Of Pharmaceutical Sciences University Of Shizuoka:(present Address)marusa Corporation
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MURATA TOSHIRO
Shizuoka College of Pharmacy
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SATO MASAKI
Shizuoka College of Pharmacy
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AIMOTO TACHIO
Shizuoka College of Pharmacy
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KIMURA RYOHEI
Shizuoka College of Pharmacy
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HAYASHI TOSHIO
Shizuoka College of Pharmacy
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AIMOTO Tachio
Fac. of Pharm. Sci., Setsunan Univ.
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Kimura Ryohei
School Of Pharmaceutical Sciences University Of Shizuoka
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Aimoto Tachio
Fac. Of Pharm. Sci. Setsunan Univ.
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SATO Masaki
the Faculty of Science and Engineering, Chuo University
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Sato Masaki
The Faculty Of Science And Engineering Chuo University
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