Studies on the Influence of PCB on Aquatic Organisms. VII. The Effect of Oral Administration of PCB on the Lipid Metabolism of the Carp

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The changes of lipid metabolism in carp caused by feeding a PCB diet were as follows. 1) In in vivo experiments, total lipid and triglyceride in the carp hepatopancreas increased slightly, and glycogen decreased. 2) In in vivo experiment, the rate of incorporation of 1-^<14>C-palmitate into the hepatopancreatic lipid fractions did not change, but the incorporation of radioactivity into blood-plasma lipid increased in the triglyceride and free fatty acid fractions, and decreased in the phospholipid and free cholesterol fractions. 3) In in vitro experiments, the incorporation of 1-^<14>C-palmitate into lipids of the hepatopancreas increased slightly in the triglyceride fraction, especially in the α, α'-position of the triglyceride. 4) The triglyceride synthetase and α-glycerophosphate dehydrogenase activities in hepatopancreas were slightly increased by PCB administration. The changes of lipid metabolism in the carp hepatopancreas on PCB administration are discussed in comparison with those in mammals.
公益社団法人日本薬学会の論文
1979-12-31