Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure(Biopharmacy)
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概要
- 論文の詳細を見る
We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl_4) at a single dose of 2.5ml/kg. There was no significant change in the total clearance (CL_<tot>) in CCl_4-treated rats, while the steady-state volume of distribution (Vd_<ss>) was significantly increased by CCl_4 treatment. Alteration in the serum unbound fraction of micafungin after CCl_4 treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vd_<ss> was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl_4 treatment.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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角 正夫
Faculty Of Pharmaceutical Sciences Setsunan University
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相本 太刀夫
Faculty Of Pharmaceutical Sciences Setsunan University
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AIMOTO Tachio
Faculty of Pharmaceutical Sciences, Setsunan University
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KONISHI Hiroki
Department of Hospital Pharmacy, of Shiga University of Medical Science
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MINOUCHI Tokuzo
Department of Hospital Pharmacy, of Shiga University of Medical Science
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YAMAJI Akira
Department of Hospital Pharmacy, of Shiga University of Medical Science
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Sumi M
Faculty Of Pharmaceutical Sciences Setsunan University
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Sumi Masaki
Department Of Hospital Pharmacy Shiga University Of Medical Science
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Yamaji A
Department Of Hospital Pharmacy Of Shiga University Of Medical Science
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Yamaji Akira
Department Of Hospital Pharmacy Shiga University Of Medical Science
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Aimoto Tachio
Faculty Of Pharmaceutical Sciences Setsunan University
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Konishi Hiroki
Department Of Hospital Pharmacy Of Shiga University Of Medical Science
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SUDO Masatomo
Department of Hospital Pharmacy, Shiga University of Medical Science
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MORII Hiroaki
Department of Hospital Pharmacy, Shiga University of Medical Science
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Sudo Masatomo
Department Of Hospital Pharmacy Shiga University Of Medical Science:faculty Of Pharmaceutical Scienc
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Morii Hiroaki
Department Of Hospital Pharmacy Shiga University Of Medical Science
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Minouchi T
Department Of Hospital Pharmacy Of Shiga University Of Medical Science
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Minouchi Tokuzo
Hospital Pharmacy Shiga University Of Medical Science
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Minouchi Tokuzo
Department Of Hospital Pharmacy Of Shiga University Of Medical Science
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相本 太刀夫
Faculty of Pharmaceutical Sciences, Setsunan University
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