PHOTOTOXICITY STUDY OF A KETOPROFEN POULTICE IN GUINEA PIGS

概要

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Ketoprofen has been reported to have such side effects as photosensitive dermatitis in humans (The Ministry of Health, Labour and Welfare, 2001). In the present study, as part of a safety evaluation of Miltax^[○!R], an application drug containing ketoprofen, phototoxicity of Miltax^[○!R] was examined in guinea pigs. In the present skin phototoxicity study, Miltax^[○!R] was applied for 12 hr. Ultraviolet (UV) rays were irradiated to examine whether or not Miltax^[○!R] elicited skin reaction. Two kinds of UV-A plus UV-B dual irradiation and UV-A single irradiation were used for the elicitation. With UV-A plus UV-B dual irradiation on the Miltax^[○!R] application site, no skin reaction was observed at UV irradiation side in any animals, in contrast to the case of the positive control article, 8-methoxypsoralen (8-MOP). Similar results were obtained with UV-A single irradiation. From these results, Miltax^[○!R] that contained ketoprofen did not show any skin phototoxicity in the guinea pig.
日本トキシコロジー学会の論文
2005-02-25