Synthesis of Isoindolo[2,1-a]quinoline Derivatives and Their Effects on N_2-Induced Hypoxia
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概要
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A variety of isoindolo[2,1-a]quinoline derivatives as well as the following related heterocycles have been prepared : 11b, 12-dihydro-5H-isoindolo[2,1-b][2]benzazepine-7,13-dione (8a), 7,8,14,14a-tetrahydroisoindolo[2,1-c][3]benzazocine, -5,13-dione(8b), 6a, 7-dihydroisoquinolino[2,3-a]quinoline-5,12-dione(12), 2,3,3a, 4-tetrahydropyrrolo[1,2-a]quinoline-1,5-dione (14), and pyrido[2', 3' : 3,4]pyrrolo[1,2-a]quinoline-5,11(5H)-dione(17). The key synthetic step involves an intramolecular Friedel-Crafts reaction of acid chlorides such as isoindole-1-acetyl chlorides (4), the acids (3) of which were prepared starting with 2-arylisoindole-1,3(2H)-diones (2-arylphthalimides)(1). The protective effects of isoindolo[2,1-a]quinoline derivatives (19 and 20) against N_2-induced hypoxia were examined. Among them, 6-(diethylaminomethyl)isoindolo[2,1-a]quinoline-5,11(5H)-dione (19b) showed the most potency.
- 社団法人日本薬学会の論文
- 1990-11-25
著者
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清田 義弘
Biology Research Laboratories:research And Development Division Takeda Chemical Industries Ltd.
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石原 雄二
Chemistry Research Laboratories
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後藤 義一
Chemistry Research Laboratories
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後藤 義一
Pharmaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries L
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石原 雄二
Pharmaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries L
関連論文
- Synthesis of Isoindolo[2,1-a]quinoline Derivatives and Their Effects on N_2-Induced Hypoxia
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