1,6-trans-N, N-Dimethyl-(6-benzyl-4,4-dimethyl-2-cyclohexenyl)methylamine塩酸塩(TAI-998)の鎮痛作用
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概要
- 論文の詳細を見る
The analgesic and morphine-like properties of TAI-998 were compared with those of codeine. TAI-998 was slightly more potent than codeine in the phenylquinone writhing test, but was less potent than codeine in the hot plate test in mice. Unlike the situation with codeine, the analgesic action of TAI-998 was not antagonized by a narcotic antagonist, and TAI-998 showed additive effects to the analgesic activities of morphine and codeine in the hot plate test. The IC_<50> value of TAI-998,in competing for ^3H-naloxone binding to rat brain homogenates was much higher than that of codeine. Codeine affected respiration, gastro-intestinal transfer of charcoal and body temperature, but TAI-998 did not.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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土居 孝行
武田薬品工業
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土居 孝行
武田薬品工業株式会社中央研究所
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加藤 武司
武田薬品工業中研
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加藤 武司
武田薬品工業株式会社中央研究所
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川井 清尚
甲子園大学栄養学部
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石井 治光
武田薬品工業株式会社中央研究所
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船堂 昌和
武田薬品工業株式会社中央研究所
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