鎮痛剤の合成研究(第8報)2-Aminomethyl-3-anilino-2-cyclohexen-1-one誘導体の還元について
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概要
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In a search for new synthetic non-narcotic analgesics, the reduction of 2-aminomethyl-3-anilino-2-cyclohexen-1-ones (I) which had both analgesic and narcotic activities was studied. 2-Aminomethyl-3-anilinocyclohexanols (IV), (6-anilino-1-cyclohexenyl) methyl-amines (VI) and (2-anilinocyclohexyl) methylamines (VIII) were obtained by reduction of the corresponding I with lithium aluminum hydride. Configurations of IV and VIII were determined by analysis of the NMR spectra of IV, VIII and their acyl derivatives. 3-(2-Chloroanilino)-5,5-dimethyl-2-piperidinomethylcyclohexanol (IVc) exhibited the most potent analgesic activity among the compounds synthesized. However, it was impossible to separate the analgesic from the narcotic activities in these compounds.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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川井 清尚
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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加藤 武司
武田薬品工業中研
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川井 清尚
Central Research Division, Takeda Chemical Industries, Ltd.
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澤 陽一
Central Research Division, Takeda Chemical Industries, Ltd.
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澤 陽一
武田薬品工業株式会社中央研究所医薬研究所
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川井 清尚
Central Research Division Takeda Chemical Industries Ltd.
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澤 陽一
Central Research Division Takeda Chemical Industries Ltd.
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