Studies on the Characteristics of Carbochromen Hydrochloride Crystals. II. Polymorphism and Cracking in the Tablets

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The cause of cracking of tablets containing carbochromen hydrochloride was further investigated in the light of the crystal modifications described in the previous paper. In tablets, form II' crystals were transformed into dihydrates (form II) upon water absorption and this led to the occurrence of capping-like cracking of the tablet. However, tablets made of form I' crystals did not crack under the same conditions. The volume expansion of form II' tablets on exposure to moisture was larger than that of form I' tablets. Apparent density variation in the tablets was measured by the drilling load method, and it was found to be uniform in form I' tablets whereas a face of discontinuity was observed in the form II' tablets. A possible explanation of these results is that form I' crystals break down on phase transformation and the tension is dispersed in all directions. In contrast, form II' crystals expand along one of their crystal axes and create distortion in the tablet.
公益社団法人日本薬学会の論文
1982-10-25