Analytical Chemical Studies on Steroids. IV. The Zimmermann Reaction of 16- and 17-Oxosteroids
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概要
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The specificity of the Zimmermann reaction was examined with 38 kinds of 16- and 17-oxosteroids. The influences of environmental situation around oxo group on the reactivities were observed and interpreted in terms of stereochemistry. Of 16-substituted 17-oxosteroids only 16-monohalo derivative showed an exceptional behaviour giving a typical Zimmermann color. By treatment of the colored solution produced from 16α-bromodehydroisoandrosterone, the Zimmermann complex, 3β-hydroxy-16ξ-(2,4-dinitrophenyl) androst-5-en-17-one, m.p. 186〜188°, was obtained and proved to be identical with that of dehydroisoandrosterone.
- 公益社団法人日本薬学会の論文
- 1965-01-25
著者
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加藤 元彦
Research And Development Division Kikkoman Corporation
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南原 利夫
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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加藤 元彦
Faculty of Pharmaceutical Sciences, University of Tokyo
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