Stereoselective Alkylation of 1-Oxoquinolizidine

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概要

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• In contrast to other nucleophilic reagents, dimethyloxosulfonium methylide and nitromethane attack 1-oxoquinolizidine (1) in a stereoselective manner to yield only the axially substituted products, quinolizidine-1-spirooxirane (2) and 1 (e)-hydroxy-1 (a)-nitromethylquinolizidine (4a). This high stereoselectivity can be explained in terms of an interaction between the lone pair on the ring nitrogen atom and the cationic center of the reagents.

• 公益社団法人日本薬学会の論文
• 1979-10-25

著者

• 佐伯 清太郎

  Faculty Of Pharmaceutical Sciences Kyushu University

• 浜名 政和

  Faculty Of Pharmaceutical Sciences Kyushu University

• 山下 絢子

  Faculty of Pharmaceutical Sciences, Kyushu University

• 松倉 陽子

  Faculty of Pharmaceutical Sciences, Kyushu University

• 松倉 陽子

  Faculty Of Pharmaceutical Sciences Kyushu University

• 山下 絢子

  Faculty Of Pharmaceutical Sciences Kyushu University

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