Studies on Tertiary Amine Oxides. LXXIX. Reactions of 2-Ethoxycarbonyl-1-hydroxyindole in the Presence of Acylating Agents
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概要
- 論文の詳細を見る
The Vilsmeier-Haack reaction of 2-ethoxycarbonyl-1-hydroxyindole (2) did not give 3-formylindoles but gave 3-chloro-2-ethoxycarbonylindole (3). The electrophilic reaction of 2 with quinoline 1-oxide (4) in the presence of benzoyl chloride or tosyl chloride also failed, 1-benzoyloxy-2-ethoxycarbonylindole (6) or 3 being formed, respectively. The reaction of 2 with tosyl chloride, benzoyl chloride or acetic anhydride gave the corresponding 3-acyloxy-2-ethoxycarbonylindoles (7,8 and 11) in unsatisfactory yields. Treatment of 2 with tosyl chloride and 1-morpholinocyclohexene in pyridine-dimethylformamide afforded 2-ethoxycarbonyl-3-(2-oxocyclohexyl) indole (13) after hydrolysis of the reaction mixture.
- 公益社団法人日本薬学会の論文
- 1984-09-25
著者
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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永吉 剛
Faculty of Pharmaceutical Sciences, Kyushu University
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永吉 剛
Faculty Of Pharmaceutical Sciences Kyushu University
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