Studies on Tertiary Amine Oxides. LVIII. Reactions of Substituted Dehydroquinolizidines with Pyridine N-Oxide. (2)
スポンサーリンク
概要
- 論文の詳細を見る
In order to introduce 2-pyridyl group into the 9 position of 1,1-disubstituted quinolizidine, N-benzoyloxypyridinium chloride (1) was treated with 9-dehydro-1-oxoquinolizidine (3), dehydro-1-ethoxycarbonyl-1-hydroxyquinolizidine (13) and 9-dehydro-1,1-ethylenedioxyquinolizidine (16) in dichloromethane, followed by reduction of the reactants with sodium borohydride in anhyd. ethanol. Although reactions with 3 and 13 gave no satisfactory result, that with 16 afforded the expected 1,1-ethylenedioxy-9-(2-pyridyl)-quinolizidine (18) in 17% yield together with dehydro-1,1-ethylenedioxy-x-(2-pyridyl)-quinolizidine (19). Other observations encountered in reactions of 1 with 3 or 13 as well as in transformation of 2 into 13 and 16 were also described in some detail.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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盛中 泰洋
Faculty Of Pharmaceutical Sciences Kyushu University
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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山下 絢子
Faculty of Pharmaceutical Sciences, Kyushu University
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山下 絢子
Faculty Of Pharmaceutical Sciences Kyushu University
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