Studies on Tertiary Amine Oxides. LIV. Reaction of Quinoline N-Oxides with Potassium Cyanate and Tosyl Chloride in Ethanol
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概要
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Quinoline 1-oxide (Ia) reacted with potassium cyanate and tosyl chloride in ethanol at -10°to give ethyl N-(2-quinolyl) carbamate (IIa) in 70% yield. The reaction under reflux caused decrease of the yield of Ia (11%) and additional formation of 2-ethoxyquinoline (IIIa) (54%) and carbostyril (IV) (29%). Unless ethanol was used, no definite product was isolated. Reactions of some derivatives of Ia as well as that of isoquinoline 2-oxide were also examined under the same conditions.
- 公益社団法人日本薬学会の論文
- 1975-10-25
著者
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浜名 政和
Faculty of Pharmaceutical Sciences, Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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熊懐 節子
Faculty of Pharmaceutical Sciences, Kyushu University
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熊懐 節子
Faculty Of Pharmaceutical Sciences Kyushu University
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