Synthetic Studies of Vitamin D Analogues. IX. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-23-oxa-, thia-, and azavitamin D_3
スポンサーリンク
概要
- 論文の詳細を見る
Three vitamin D_3 analogues, 1α, 25-dihydroxy-23-oxavitamin D_3 (3), 1α, 25-dihydroxy-23-thiavitamin D_3 (4) and 1α, 25-dihydroxy-23-azavitamin D_3 (5) were synthesized. In the differentiation-inducing activity of human myeloid leukemia cells into macrophages in vitro, the 23-aza analogue (5) showed the least activity, while no remarkable differences were observed between the 23-oxa analogue (3) and the 23-thia analogue (4), which were less active than 1α, 25-dihydroxyvitamin D_3 (1).
- 社団法人日本薬学会の論文
- 1991-12-25
著者
-
久保寺 登
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
松本 雅彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
宮本 勝仁
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
秋山 正司
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
森 隆司
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
秋山 正司
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
宮本 勝仁
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
森 隆司
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
関連論文
- Synthetic Studies of Vitamin D Analogues. XVII.Synthesis and Differentiation-Inducing Activity of 1α, 24-Dihydroxy-22-oxavitamin D_3 Analogues and Their 20(R)-Epimers
- Synthetic Studies of Vitamin D Analogues. XI. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-22-oxavitamin D_3 Analogues
- Synthetic Studies of Vitamin D Analogues. X. Synthesis and Biological Activities of 1α, 25-Dihydroxy-21-norvitamin D_3
- Synthetic Studies of Vitamin D Analogues. IX. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-23-oxa-, thia-, and azavitamin D_3
- Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate(Medicinal Chemistry,Chemical)
- Production and Specificity of Anti-22-oxacalcitriol Antisera
- 側鎖に酸素原子を含む新規ビタミンD_3誘導体の生理活性 : In vivo : 第40回大会研究発表要旨
- 側鎖に酸素原子を含む新規ビタミンD_3誘導体の生理活性 : In vitro : 第40回大会研究発表要旨
- 側鎖に酸素原子を含む新規ビタミンD_3誘導体の生理活性 : 脂溶性ビタミン総合研究委員会 : 第229回会議研究発表要旨
- 5.カルシウム代謝調節作用を有する新規ビタミンD_3誘導体 : 2β-(3-hydroxy-propoxy)-1α,25-(OH)_2-D_3(その2)(第235回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
- 4.カルシウム代謝調節作用を有する新規ビタミンD_3誘導体 : 2β-(3-hydoxy-propoxy)-1α,25-(OH)_2-D_3(その1)(第235回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
- 2-II-30 新規ビタミンD_3誘導体 : 2β-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D_3の薬理作用について(その2)(第41回大会一般研究発表)
- 2-II-29 新規ビタミンD_3誘導体 : 2β-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D_3の薬理作用について(その1)(第41回大会一般研究発表)
- SYNTHETIC STUDIES OF VITAMIN D_3 ANALOGUES. VIII. : SYNTHESIS OF 22-OXAVITAMIN D_3 ANALOGUES
- SYNTHETIC STUDIES OF VITAMIN D ANALOGUES. VII. : SYNTHESIS OF 20-OXA-21-NORVITAMIN D_3 ANALOGUES
- Synthetic Studies of Vitamin D Analogues. XIV. Synthesis and Calcium Regulating Activity of Vitamin D_3 Analogues Bearing a Hydroxyalkoxy Group at the 2β-Position