Effects of Derivatives of Hydroxypyruvaldehyde Phenylosazone on the Ca^<2+>-Adenosine Triphosphatase Activity of Porcine Erythrocyte Membrane

概要

論文の詳細を見る
Thirteen derivatives of hydroxypyruvaldehyde phenylosazone were tested for their effects on the Ca^<2+>-adenosine triphosphatase (ATPase) activity of porcine erythrocyte membranes. Seven drugs including hydroxypyruvaldehyde phenylosazone itself and the m-CH_3,p-CH_3,o-Cl, p-Cl, 3,4-di-Cl and p-Br derivatives, inhibited Ca^<2+>-ATPase activity, while other derivatives such as o-CH_3,2,4-di-Cl, 2,5-di-Cl, o-NO_2,m-NO_2 and p-NO_2 derivatives were essentially without effect. Hydroxypyruvaldehyde p-chlorophenylosazone was the most potent inhibitor, inhibiting the enzyme activity completely at 1 mM, whereas carbonylcyanide m-chlorophenylhydrazone, a typical inhibitor of Ca^<2+>-ATPase, inhibited the activity by 85% at the same concentration.
社団法人日本薬学会の論文
1985-08-25