Synthesis of Fluorescein Monoglucuronide

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概要

• 論文の詳細を見る

• Fluorescein monoglucuronide (III), the main metabolite of fluorescein (I), was chemically synthesized by means of the Koenigs-Knorr reaction. Nuclear magnetic resonance (NMR) spectra and mass spectra (MS) showed that the synthesized material was monoglucuronidated fluorescein. The changes in absorption spectra with pH indicated that this material was an "ether" glucuronide. The glucuronoside linkage was concluded to be β, since this material was hydrolyzed by β-glucuronidase. Thus, the synthesized material was confirmed to be fluorescein mono-β-D-glucuronide.

• 社団法人日本薬学会の論文
• 1984-07-25

著者

• 松永 功

  New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 長瀧 重智

  Department Of Ophthalmology School Of Medicine University Of Tokyo

• 田村 善蔵

  School of Medicine, Keio University

• 田村 善蔵

  School Of Medicine Keio University

• 松永 功

  New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.

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