A New Ring Transformation of 3,4-Dihydro-1-methyl-6-phenyl-1,4,5-benzotriazocin-2 (1H)-ones into 1-(Methylcarbamoyl)-methyl-3-phenyl-1H-indazoles
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概要
- 論文の詳細を見る
3,4-Dihydro-1-methyl-6-phenyl-1,4,5-benzotriazocin-2 (1H)-one (1a) readily undergoes a transformation into 1-(methylcarbamoyl) methyl-3-phenyl-1H-indazole (3a) when its chloroform solution is kept at room temperature. The 8-chloro, 8-bromo and 8-fluoro derivatives of 1a (1b, 1c and 1d) similarly afford the corresponding 5-halogenoindazoles (3b, 3c and 3d), but 3,4-dihydro-6-phenyl-1,4,5-benzotriazocin-2 (1H)-one, and its 1-benzyl and 1-dialkylaminoalkyl derivatives give no ring contraction product under the same conditions.
- 社団法人日本薬学会の論文
- 1984-08-25
著者
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藤村 保夫
中外製薬新薬研究所
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永野 洋幸
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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松永 功
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新藤 実
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新藤 実
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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永野 洋幸
Central Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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