Reactions of Nicotinic Acid 1-Oxide with Propionic, Phenylacetic and Benzoic Anhydrides(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Nicotinic acid 1-oxide (1) reacts with hot propionic anhydride to give 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone 4-oxide (2), 5-aza-3-methyl-4-propionyloxyisocoumarin (3), 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone (4), 4-aza-3-ethyl-3,5-dipropionyloxy-1(3H)-isobenzofuranone (5) and a mixture of 2 and 6-hydroxynicotinic acids (6 and 7). Product 2 is a 2-propionylation product of 1, and 3, 4 and 5 arise from further action of the anhydride on 2. Phenylacetic anhydride undergoes oxidative decarboxylation with 1 to give benzaldehyde and nicotinic acid. The reaction of 1 with benzoic anhydride affords a 2-benzoylation product, 4-aza-3-benzoyloxy-3-phenyl-1(3H)-isobenzofuranone 4-oxide (12).
- 公益社団法人日本薬学会の論文
- 1987-10-25
著者
-
永野 洋幸
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
-
永野 洋幸
Central Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
縄田 喜治
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
-
浜名 政和
Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.
-
浜名 政和
Central Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
縄田 喜治
Central Research Laboratories Chugai Pharmaceutical Co. Ltd.
関連論文
- 26 Cholesterolからの1α,25-Dihydroxycholecalciferol〔1α,25(OH)_2-D_3〕の合成
- A New Ring Transformation of 3,4-Dihydro-1-methyl-6-phenyl-1,4,5-benzotriazocin-2 (1H)-ones into 1-(Methylcarbamoyl)-methyl-3-phenyl-1H-indazoles
- 5.肝における 1α-Hydroxyvitamin D_3の 1α, 25-Dihydroxyvitamin D_3への代謝(脂溶性ビタミン総合研究委員会 : 第156回会議研究発表要旨)
- Reactions of Nicotinic Acid 1-Oxide with Propionic, Phenylacetic and Benzoic Anhydrides(Organic,Chemical)
- The Mechanism of the Reaction of Nicotinic Acid 1-Oxide with Acetic Anhydride(Organic,Chemical)
- 4-Nitro-及び5-Nitro-N-(2-nitroxyethyl)nicotinamideの合成
- Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.