Studies on Uricosuric Diuretics. II. Substituted 7,8-Dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic Acids and 7,8-Dihydrofuro[2,3-g]benzoxazole-7-carboxylic Acids
スポンサーリンク
概要
- 論文の詳細を見る
A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids 9 and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids 12 were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives 9 showed uricosuric and only weak diuretic activities, whereas the benzoxazoles 12 exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole 7-carboxylic acid (9b, AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
-
田中 晴子
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
佐藤 晴彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
古賀 弘
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
段 孝
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
小沼 悦郎
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
青木 文弥
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
青木 文弥
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
小沼 悦郎
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
Onuma Etsuro
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
Onuma Etsuro
Kamakura Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
段 孝
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
関連論文
- Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate(Medicinal Chemistry,Chemical)
- Studies on Uricosuric Diuretics. III. Substituted 1,3-Dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic Acids and 1,3-Dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic Acids
- Studies on Uricosuric Diuretics. II. Substituted 7,8-Dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic Acids and 7,8-Dihydrofuro[2,3-g]benzoxazole-7-carboxylic Acids
- Studies on Uricosuric Diuretics. I. : Syntheses and Activities of Xanthonyloxyacetic Acids and Dihydrofuroxanthone-2-carboxylic Acids
- Studies on Uricosuric Diuretics. V. Convenient and Efficient Synthesis of 2,3-Dihydrobenzofuran Derivatives
- Novel Rearrangement of Pyrazole N-Imines with Acetic Anhydride
- Syntheses of Novel Antimicrobial Compounds : Pyrazolo [5,1-b] thiazole, Imidazo [1,2-b] pyrazole, and Thiazolo [3,2-b] dihydro-1,2-diazepine
- Hypothalamic Neuropeptides and Appetite Response in Anorexia-Cachexia Animal
- Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma
- Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure-Activity Relationships of Its Derivatives
- Errata: Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure–Activity Relationships of Its Derivatives [Chem. Pharm. Bull. 56(11): 1555-1561 (2008)]