Malonylginsenoside Rb_1 Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth of Cultured Chick Embryonic Dorsal Root Ganglia

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概要

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• Effects of malonylginsenoside Rb_1 (GRb_<1-m>) isolated from dried root of Panax ginseng C. A. MEYER (Araliaceae) on neuronal survival and neurite outgrowth were compared with those of ginsenoside Rb_1 (GRb_1) using organ culture of chick embryonic dorsal root ganglia (DRG) and cell culture of DRG neurons. In the organ culture, nerve growth factor (NGF) showed neurite outgrowth promoting effect. GRb_<1-m>(30μM) significantly potentiated this NGF-induced neurite outgrowth with similar potency to that of GRb_1 (30μM). Low density cell culture of DRG neurons was employed to minimize the contribution of contaminating non-neuronal cells. NGF (10 ng/ml) prolonged duration of neuronal survival. Neither GRb_<1-m> nor GRb_1 (1-30μM) changed the prolongation effect of NGF, nor did NGF show a significant effect on the neurite elongation and re-elongation after axotomy by laser beam irradiation. However, GRb_<1-m> (10μM) potentiated initial neurite elongation when co-treated with NGF. In the process of re-elongation of neurites, GRb_<1-m> (1,30μM) also promoted it in the presence of NGF. These results suggest, first, that GRb_<1-m> potentiates NGF-induced neurite outgrowth of chick embryonic DRGs and DRG neurons, but behaves in a slightly different manner from GRb_1,and, second, that the effects of the two saponins may work primarily on neurons causing the potentiation of NGF-induced neurite outgrowth.

• 公益社団法人日本薬学会の論文
• 1994-04-15

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 西山 信好

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

• 齊藤 洋

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 西山 信好

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 齊藤 洋

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Nishiyama Nobuyoshi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University

• 趙 成益

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

• 趙 成益

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

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