Beneficial Effects of S-113m, a Novel Herbal Prescription, on Learning Impairment Model in Mice
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概要
- 論文の詳細を見る
The effects of S-113m, a novel herbal prescription consisting of Biota orientalis, Panax ginseng and Schisandra chinensis, were studied regarding learning and memory performance in the step-down and lever-press tests in normal, as well as in learning-impaired, mice. The prescription had no effect on memory registration, consolidation and retrieval processes or on motor activity in normal mice. However, a single oral administration of S-113m at doses of 250 and 500 mg/kg reduced the ethanol-induced and scopolamine-induced impairment of memory registration in the step-down test. The preparation also improved the electroconvulsive shock-induced impairment of memory consolidation in the same test. S-113m did not, however, attenuate the ethanol-induced impairment of memory retrieval. These results suggest that S-113m has a preferential beneficial effect on the impairment of memory registration and memory consolidation rather than on memory retrieval in mice, through direct action on the learning and memory processes.
- 公益社団法人日本薬学会の論文
- 1995-11-15
著者
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齋藤 洋
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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西山 信好
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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西山 信好
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Wang Y‐l
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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王 元〓
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Nishiyama Nobuyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University
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王 元〓
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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