An Herbal Prescription, S-113m, Consisting of Biota, Ginseng and Schizandra, Improves Learning Performance in Senescence Accelerated Mouse
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概要
- 論文の詳細を見る
The effect of an herbal prescription, S-113m, consisting of biota, ginseng and schizandra, on learning and memory performance was studied in the senescence accelerated mouse (SAM). A solid diet containing 1% (w/w) S-113m was given to SAM from 1 month of age. A behavioral experiment, started 4 or 9 months later, revealed prominent learning impairment in SAMP8,a senescence accelerated-prone mouse. Chronic ingestion of S-113m improved the memory retention disorder of SAMP8 in a passive avoidance test and increased the conditioned avoidance rate in a lever-press test at the age of 10 months. The preparation also facilitated the memory retention deficit in the passive avoidance test in 10-month-old SAMR1,a senescent substrain. These results raise the possibility that S-113m might be useful for treating physiological aging and age-related memory deficits in human.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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Nishiyama Nobuyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Chu P‐j
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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CHU Pen-Jiang
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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